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Key Documents

SML1052

Sigma-Aldrich

2-D08

≥98% (HPLC)

Synonyme(s) :

2′,3′,4′-trihydroxy-flavone, 2-(2,3,4-Trihydroxyphenyl)-4H-1-Benzopyran-4-one

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About This Item

Formule empirique (notation de Hill):
C15H10O5
Numéro CAS:
144707-18-6
Poids moléculaire :
270.24
Code UNSPSC :
12352200
Nomenclature NACRES :
NA.77

Pureté

≥98% (HPLC)

Forme

powder

Couleur

white to beige

Solubilité

DMSO: 20 mg/mL, clear

Température de stockage

2-8°C

Application

2-D08 has been used as a small ubiquitin-like modifier (SUMO)ylation inhibitor.

Actions biochimiques/physiologiques

2-D08 is a potent and cell-permeable inhibitor of sumoylation that block the transfer of SUMO (small ubiquitin-like modifier) from the E2 enzyme (Ubc9) thioester conjugate to the substrate.

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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Consulter la Bibliothèque de documents

MG132?induced progerin clearance is mediated by autophagy activation and splicing regulation.
Harhouri K, et al.
EMBO Molecular Medicine (2017)
RAS GTPases are modified by SUMOylation.
Choi B H, et al.
Oncotarget, 9(4), 4440-4440 (2018)
Byeong Hyeok Choi et al.
Oncotarget, 9(4), 4440-4450 (2018-02-13)
RAS proteins are GTPases that participate in multiple signal cascades, regulating crucial cellular processes including cell survival, proliferation, differentiation, and autophagy. Mutations or deregulated activities of RAS are frequently the driving force for oncogenic transformation and tumorigenesis. Given the important
Pan Zhou et al.
Biochemical and biophysical research communications, 513(4), 1063-1069 (2019-04-24)
Acute myeloid leukemia (AML) is a heterogeneous clonal hematopoietic malignancy with poor survival and frequent relapse. Recently, a posttranslational modification of proteins with small ubiquitin-like modifiers (SUMO) has been notably implicated in a wide spectrum of diseases, especially cancers. Ubc9
Karim Harhouri et al.
EMBO molecular medicine, 9(9), 1294-1313 (2017-07-05)
Hutchinson-Gilford progeria syndrome (HGPS) is a lethal premature and accelerated aging disease caused by a de novo point mutation in LMNA encoding A-type lamins. Progerin, a truncated and toxic prelamin A issued from aberrant splicing, accumulates in HGPS cells' nuclei
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