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Key Documents

SAB4700101

Sigma-Aldrich

Monoclonal Anti-CD14-PE antibody produced in mouse

clone MEM-15, purified immunoglobulin, buffered aqueous solution

Synonyme(s) :

Anti-LPS-receptor

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About This Item

Code UNSPSC :
12352203
Nomenclature NACRES :
NA.44

Source biologique

mouse

Conjugué

phycoerythrin (R-PE) conjugate

Forme d'anticorps

purified immunoglobulin

Type de produit anticorps

primary antibodies

Clone

MEM-15, monoclonal

Forme

buffered aqueous solution

Espèces réactives

nonhuman primates, human

Technique(s)

flow cytometry: suitable

Isotype

IgG1

Numéro d'accès NCBI

NM_000591.3

Numéro d'accès UniProt

P08571

Conditions d'expédition

wet ice

Température de stockage

2-8°C

Modification post-traductionnelle de la cible

unmodified

Informations sur le gène

human ... CD14(929)

Description générale

CD14 (cluster of differentiation 14) is a myelomonocytic differentiation antigen, encoded by the gene mapped to human chromosome 5q23-31. It is mainly expressed by monocytes, macrophages and activated granulocytes.

Immunogène

A crude mixture of human urinary proteins precipitated by ammonium sulphate from the urine of a patient suffering from proteinuria

Application

The reagent is designed for Flow Cytometry analysis of human blood cells using 20 μL reagent / 100 μL of whole blood or 1e6 cells in a suspension. The content of a vial (2 mL) is sufficient for 100 tests.

Actions biochimiques/physiologiques

CD14 (cluster of differentiation 14) serves as an important receptor of bacterial lipopolysaccharide (LPS). CD14 and LPs complex interacts with toll-like receptor 4 and enhances the expression of inflammatory mediators, including tumor necrosis factor (TNF)- and interleukin (IL)-1, via p38 mitogen-activated protein kinase and nuclear factor-B pathway. Mutation in the gene is associated with the development of myeloid leukemias and generalized chronic periodontitis (GCP).

Caractéristiques et avantages

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Forme physique

Solution in phosphate buffered saline containing 15 mM sodium azide and 0.2% high-grade protease free BSA as a stabilizing agent.

Clause de non-responsabilité

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Code de la classe de stockage

10 - Combustible liquids

Classe de danger pour l'eau (WGK)

WGK 2

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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Consulter la Bibliothèque de documents

The CD14 monocyte differentiation antigen maps to a region encoding growth factors and receptors.
Goyert SM
Science, 239, 497-500 (1988)
Synergistic contribution of CD14 and HLA loci in the susceptibility to Buerger disease
Chen Z
Human Genetics, 122, 367-372 (2007)
Cytogenetic and molecular delineation of the smallest commonly deleted region of chromosome 5 in malignant myeloid diseases
Le Beau MM
Proceedings of the National Academy of Sciences of the USA, 90, 5484-5488 (1993)
Dilshi Ishaan et al.
Genetic testing and molecular biomarkers, 21(9), 560-564 (2017-08-23)
The genetic variation in the CD14 rs2569190 promoter region contributes to the susceptibility of developing periodontitis. Since, CD14 gene polymorphism studies among various ethnic populations have produced conflicting results, the present study was designed to unearth the association between the

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