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Key Documents

SAB4300032

Sigma-Aldrich

Anti-phospho-STAT1 (pTyr701) antibody produced in rabbit

affinity isolated antibody

Synonyme(s) :

Anti-DKFZp686B04100 antibody produced in rabbit, Anti-ISGF-3 antibody produced in rabbit, Anti-STAT91 antibody produced in rabbit, Anti-signal transducer and activator of transcription 1, 91kDa antibody produced in rabbit

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About This Item

Numéro MDL:
MFCD01633987
Code UNSPSC :
12352203
Nomenclature NACRES :
NA.41

Source biologique

rabbit

Conjugué

unconjugated

Forme d'anticorps

affinity isolated antibody

Type de produit anticorps

primary antibodies

Clone

polyclonal

Forme

buffered aqueous solution

Poids mol.

~91 kDa

Espèces réactives

human, mouse

Concentration

1 mg/mL

Technique(s)

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:50-1:100
western blot: 1:500-1:1000

Isotype

IgG

Séquence immunogène

(T-G-YP-I-K)

Numéro d'accès NCBI

NP_009330.1

Numéro d'accès UniProt

P42224

Conditions d'expédition

wet ice

Température de stockage

−20°C

Modification post-traductionnelle de la cible

phosphorylation (pTyr701)

Informations sur le gène

human ... STAT1(6772)

Description générale

Signal transducer and activator of transcription 1 (STAT1) gene is mapped to human chromosome 2q32.2. It is part of the STAT family of proteins. STAT1 exists in two isoforms, STAT1α and STAT1β with molecular weight of 91kDa and 84kDa, respectively. The protein shows ubiquitous expression.

Immunogène

Peptide sequence around phosphorylation site of tyrosine 701 (T-G-Y(p)-I-K), according to the protein STAT1.

Actions biochimiques/physiologiques

Signal transducer and activator of transcription 1 (STAT1) plays a vital role in interferon (IFN) signaling. Phospho-STAT1 regulates pro- and anti-apoptotic genes following several stress-induced responses. It interacts with p53 and promotes p53-mediated transcriptional gene activity and apoptosis. STAT1 is also an essential factor of stress-induced and DNA damage-induced checkpoint pathways and thus, acts as a tumor suppressor.

Caractéristiques et avantages

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Forme physique

Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol

Clause de non-responsabilité

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Réf. du produit
Description
Tarif

Code de la classe de stockage

10 - Combustible liquids

Classe de danger pour l'eau (WGK)

WGK 1

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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Consulter la Bibliothèque de documents

cDNA cloning, expression and chromosome mapping of the human STAT4 gene: both STAT4 and STAT1 genes are mapped to 2q32.2-->q32.3.
Yamamoto K
Cytogenetics and Cell Genetics (1997)
Epigallocatechin-3-gallate inhibits STAT-1 activation and protects cardiac myocytes from ischemia/reperfusion-induced apoptosis.
Faseb Journal (2004)
STAT-1: a novel regulator of apoptosis.
Stephanou A and Latchman DS
International Journal of Experimental Pathology (2003)
Assignment1 of STAT1 to human chromosome 2q32 by FISH and radiation hybrids.
Haddad B
Cytogenetics and Cell Genetics (1998)

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