S8753

Strychnine hydrochloride

• Formule empirique (notation de Hill): C₂₁H₂₂N₂O₂ · HCl
• Numéro CAS: 1421-86-9
• Poids moléculaire : 370.87
• Numéro CE : 215-826-9
• Numéro MDL: MFCD00058174
• Code UNSPSC : 12352210
• ID de substance PubChem : 24899812
• Nomenclature NACRES : NA.32

Propriétés

• Niveau de qualité: 100
• Chaîne SMILES: Cl.[H][C@@]12CC(=O)N3c4ccccc4[C@]56CCN7CC(=CCO1)[C@]([H])(C[C@@]57[H])[C@]2([H])[C@]36[H]
• InChI: 1S/C21H22N2O2.ClH/c24-18-10-16-19-13-9-17-21(6-7-22(17)11-12(13)5-8-25-16)14-3-1-2-4-15(14)23(18)20(19)21;/h1-5,13,16-17,19-20H,6-11H2;1H/t13-,16-,17-,19-,20-,21+;/m0./s1
• Clé InChI: VLXYTKMPCOQKEM-ZEYGOCRCSA-N

Description

Application

Strychnine hydrochloride has been used as a glycine receptor antagonist in the retina for biophysiological functions. It has also been used to block glutamatergic, GABAergic and glycinergic receptors and gap junctions.

Actions biochimiques/physiologiques

Convulsant; glycine receptor antagonist not associated with the NMDA receptor.

Strychnine is a potent convulsant, which is extracted from Strychnos nux vomica seeds. At high doses, the compound causes convulsions and ultimately death due to respiratory paralysis. Strychnine acts as a respiratory, circulatory and digestive stimulant.

Informations sur la sécurité

• Pictogrammes: GHS06,GHS09
• Mention d'avertissement: Danger
• Mentions de danger: H300 + H330,H410
• Conseils de prudence: P260 - P264 - P271 - P273 - P284 - P304 + P340 + P310
• Classification des risques: Acute Tox. 2 Inhalation - Acute Tox. 2 Oral - Aquatic Acute 1 - Aquatic Chronic 1
• Code de la classe de stockage: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• Équipement de protection individuelle: Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges