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Merck
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R9525

Sigma-Aldrich

RX 821002 hydrochloride

solid, ≥98% (HPLC)

Synonyme(s) :

2-[2-(2-Methoxy-1,4-benzodioxanyl)]imidazoline hydrochloride

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About This Item

Formule empirique (notation de Hill):
C12H14N2O3 · HCl
Numéro CAS:
109544-45-8
Poids moléculaire :
270.71
Numéro MDL:
MFCD00069343
Code UNSPSC :
12352200
ID de substance PubChem :
24278684
Nomenclature NACRES :
NA.77

Pureté

≥98% (HPLC)

Forme

solid

Conditions de stockage

desiccated

Couleur

white

Solubilité

H2O: >20 mg/mL

Chaîne SMILES 

Cl[H].COC1(COc2ccccc2O1)C3=NCCN3

InChI

1S/C12H14N2O3.ClH/c1-15-12(11-13-6-7-14-11)8-16-9-4-2-3-5-10(9)17-12;/h2-5H,6-8H2,1H3,(H,13,14);1H

Clé InChI

IMPOOMVZVWKSAP-UHFFFAOYSA-N

Informations sur le gène

human ... ADRA2A(150) , ADRA2B(151) , ADRA2C(152)

Actions biochimiques/physiologiques

Selective α2-adrenoceptor antagonist

Pictogrammes

Exclamation mark
GHS07

Mention d'avertissement

Warning

Mentions de danger

H315,H319,H335

Classification des risques

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Organes cibles

Respiratory system

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Équipement de protection individuelle

dust mask type N95 (US), Eyeshields, Gloves

Certificats d'analyse (COA)

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Consulter la Bibliothèque de documents

J Galitzky et al.
British journal of pharmacology, 100(4), 862-866 (1990-08-01)
1. The binding of a new alpha 2-adrenoceptor antagonist, [3H]-RX821002 (2-(2-methoxy-1,4-benzodioxan-2-yl)-2-imidazoline), was investigated in human platelet membranes and compared with [3H]-yohimbine binding parameters. 2. Analysis of kinetic data revealed association and dissociation time courses consistent with a simple biomolecular reaction.
S J Rayment et al.
British journal of pharmacology, 160(7), 1727-1740 (2010-07-24)
We have investigated the distribution of alpha-adrenoceptors in sheep internal anal sphincter (IAS), as a model for the human tissue, and evaluated various imidazoline derivatives for potential treatment of faecal incontinence. Saturation and competition binding with (3)H-prazosin and (3)H-RX821002 were
S Gasparini et al.
Neuroscience, 164(2), 370-379 (2009-09-01)
The blockade of serotoninergic receptors with methysergide or the activation of alpha(2)-adrenoceptors with moxonidine into the lateral parabrachial nucleus (LPBN) increases water and 0.3 M NaCl intake in rats treated with furosemide (FURO) combined with captopril (CAP). In the present
Axel Rominger et al.
Synapse (New York, N.Y.), 64(8), 654-657 (2010-03-26)
To test for alpha(2) adrenergic modulation of dopamine D(2/3) receptor availability in striatum of living mice using the high-affinity ligand [(18)F]fallypride and microPET. Groups of anesthetized mice were pretreated with saline, the alpha(2)-agonist clonidine (1 mg/kg), and the alpha(2)-antagonists RX821002
M M Rank et al.
Journal of neurophysiology, 105(1), 410-422 (2010-11-05)
The brain stem provides most of the noradrenaline (NA) present in the spinal cord, which functions to both increase spinal motoneuron excitability and inhibit sensory afferent transmission to motoneurons (excitatory postsynaptic potentials; EPSPs). NA increases motoneuron excitability by facilitating calcium-mediated
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