N7758

Naloxone hydrochloride dihydrate

≥98% (TLC and titration), powder

• Formule empirique (notation de Hill): C₁₉H₂₁NO₄ · HCl · 2H₂O
• Numéro CAS: 51481-60-8
• Poids moléculaire : 399.87
• Numéro Beilstein : 6260807
• Numéro MDL: MFCD00150901
• Code UNSPSC : 12352200
• ID de substance PubChem : 24278050
• Nomenclature NACRES : NA.77

Propriétés

• Pureté: ≥98% (TLC and titration)
• Forme: powder
• Activité optique: [α]25/D −178.6°, c = 2.5 in H₂O(lit.)
• Couleur: white to off-white
• Solubilité: ethanol: 3.3 mg/mL; H₂O: 50 mg/mL
• Température de stockage: 2-8°C
• Chaîne SMILES: O.O.Cl.Oc1ccc2C[C@H]3N(CC[C@@]45[C@@H](Oc1c24)C(=O)CC[C@@]35O)CC=C
• InChI: 1S/C19H21NO4.ClH.2H2O/c1-2-8-20-9-7-18-15-11-3-4-12(21)16(15)24-17(18)13(22)5-6-19(18,23)14(20)10-11;;;/h2-4,14,17,21,23H,1,5-10H2;1H;2*1H2/t14-,17+,18+,19-;;;/m1.../s1
• Clé InChI: TXMZWEASFRBVKY-IOQDSZRYSA-N
• Informations sur le gène: human ... OPRD1(4985) , OPRK1(4986) , OPRM1(4988) , OPRS1(10280)

Description

Application

Naloxone hydrochloride dihydrate has been used in:

• isotonic saline and injected subcutaneously into experimental rats to study its involvement with withdrawal syndrome in morphine-dependent rats
• as opioid receptor antagonist to examine the role of the endogenous opioid system in infantile amnesia for contextual fear
• as a reference neutral antagonist to define the maximum effect (Emax) of the system

Actions biochimiques/physiologiques

Competitive antagonist for μ, κ, δ, and σ opioid receptors; blocks the action of σ-agonists at opioid sites. Naloxone′s antagonistic effect last for about 45 min and thus, requires repeated dosage. It results in critical side effects such as pulmonary edema.

Caractéristiques et avantages

This compound is featured on the Opioid Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Attention

Light sensitive.

Informations sur la sécurité

• Pictogrammes: GHS07
• Mention d'avertissement: Warning
• Mentions de danger: H315,H319,H335
• Conseils de prudence: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Classification des risques: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• Organes cibles: Respiratory system
• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• Équipement de protection individuelle: dust mask type N95 (US), Eyeshields, Gloves