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G0923

Sigma-Aldrich

Golgicide A

≥98% (HPLC)

Synonyme(s) :

6,8-Difluoro-4-pyridin-3-yl-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinoline, CID 25113626, GCA

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About This Item

Formule empirique (notation de Hill):
C17H14F2N2
Numéro CAS:
1005036-73-6
Poids moléculaire :
284.30
Code UNSPSC :
12352200
ID de substance PubChem :
329799717
Nomenclature NACRES :
NA.77

Pureté

≥98% (HPLC)

Forme

solid

Solubilité

DMSO: >10 mg/mL

Température de stockage

room temp

Chaîne SMILES 

Fc1cc(F)c2NC([C@@H]3CC=C[C@@H]3c2c1)c4cccnc4

InChI

1S/C17H14F2N2/c18-11-7-14-12-4-1-5-13(12)16(10-3-2-6-20-9-10)21-17(14)15(19)8-11/h1-4,6-9,12-13,16,21H,5H2/t12-,13+,16?/m0/s1

Clé InChI

NJZHEQOUHLZCOX-FTLRAWMYSA-N

Application

Golgicide A has been used as an inhibitor in retrotransposition assays and as an inhibitor of Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1 protein (GBF1) in HeLa cells.

Actions biochimiques/physiologiques

Golgicide A is a potent, highly specific, reversible inhibitor of the cis-Golgi ArfGEF GBF1. Arf proteins are members of the Ras superfamily of small guanosine triphosphatases (GTPases) that mediate vesicular transport. Golgicide A binds within an interfacial cleft formed between Arf1 and the GBF1 Sec7 domain. Golgicide A is a unique and powerful tool for further elucidating the mechanisms underlying assembly and transport within the Golgi, comparable to the use of dynasore for studying the dynamics of dynamin-mediated clathrin coat formation.

Caractéristiques et avantages

This compound is a featured product for Cyclic Nucleotide research. Click here to discover more featured Cyclic Nucleotide products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

Pictogrammes

Exclamation mark
GHS07

Mention d'avertissement

Warning

Mentions de danger

H319

Classification des risques

Eye Irrit. 2

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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Retrouvez la documentation relative aux produits que vous avez récemment achetés dans la Bibliothèque de documents.

Consulter la Bibliothèque de documents

Ying Wu et al.
BMC genomics, 19(1), 705-705 (2018-09-27)
Powdery mildew (PM) is one of the most important and widespread plant diseases caused by biotrophic fungi. Notably, while monocot (grass) PM fungi exhibit high-level of host-specialization, many dicot PM fungi display a broad host range. To understand such distinct
Silke Peter et al.
BMC genomics, 18(1), 859-859 (2017-11-12)
Pseudomonas putida is a Gram-negative, non-fermenting bacterium frequently encountered in various environmental niches. P. putida rarely causes disease in humans, though serious infections and outbreaks have been reported from time to time. Some have suggested that P. putida functions as
Sravani Banerjee et al.
PLoS pathogens, 14(5), e1007086-e1007086 (2018-05-22)
RNA viruses induce specialized membranous structures for use in genome replication. These structures are often referred to as replication organelles (ROs). ROs exhibit distinct lipid composition relative to other cellular membranes. In many picornaviruses, phosphatidylinositol-4-phosphate (PI4P) is a marker of
Don Gilden et al.
Neurology, 84(19), 1948-1955 (2015-02-20)
Varicella-zoster virus (VZV) infection may trigger the inflammatory cascade that characterizes giant cell arteritis (GCA). Formalin-fixed, paraffin-embedded GCA-positive temporal artery (TA) biopsies (50 sections/TA) including adjacent skeletal muscle and normal TAs obtained postmortem from subjects >50 years of age were
Danelle K Seymour et al.
Proceedings of the National Academy of Sciences of the United States of America, 113(46), E7317-E7326 (2016-11-03)
The ubiquity of nonparental hybrid phenotypes, such as hybrid vigor and hybrid inferiority, has interested biologists for over a century and is of considerable agricultural importance. Although examples of both phenomena have been subject to intense investigation, no general model
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