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D7071

Sigma-Aldrich

Dapoxetine hydrochloride

≥98% (HPLC)

Synonyme(s) :

(S)-N,N-dimethyl-1-phenyl-3-(1-naphthalenyloxy)propanamine hydrochloride, S-(+)-N,N-dimethyl-a-[2-(naphthalenyloxy)ethyl] benzenemethanamine hydrochloride, LY-210448 hydrochloride

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About This Item

Formule empirique (notation de Hill):
C21H23NO · HCl
Numéro CAS:
129938-20-1
Poids moléculaire :
341.87
Numéro MDL:
MFCD08272809
Code UNSPSC :
12352200
ID de substance PubChem :
329798842
Nomenclature NACRES :
NA.77

Pureté

≥98% (HPLC)

Forme

powder

Activité optique

[α]/D +125 to +135°, c = 1 in methanol

Conditions de stockage

desiccated

Couleur

white

Solubilité

DMSO: ≥20 mg/mL

Auteur

Eli Lilly

Température de stockage

room temp

Chaîne SMILES 

Cl.CN(C)[C@@H](CCOc1cccc2ccccc12)c3ccccc3

InChI

1S/C21H23NO.ClH/c1-22(2)20(18-10-4-3-5-11-18)15-16-23-21-14-8-12-17-9-6-7-13-19(17)21;/h3-14,20H,15-16H2,1-2H3;1H/t20-;/m0./s1

Clé InChI

IHWDIQRWYNMKFM-BDQAORGHSA-N

Informations sur le gène

human ... SLC6A4(6532)

Description générale

Dapoxetine ((+)-(S)-N,N-dimethyl-(α)-[2(1naphthal enyloxy)ethyl]-benzenemethanamine hydrochloride) possess a similar structure as that of fluoxetine.

Actions biochimiques/physiologiques

Dapoxetine is capable of blocking recombinant Kv4.3 potassium voltage-gated channels. It is considered as safe.
Potent Selective serotonin reuptake inhibitor (SSRI); used in treatment of premature ejaculation

Caractéristiques et avantages

This compound is featured on the Biogenic Amine Transporters page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by Eli Lilly. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Pictogrammes

Exclamation mark
GHS07

Mention d'avertissement

Warning

Mentions de danger

H302,H319,H413

Classification des risques

Acute Tox. 4 Oral - Aquatic Chronic 4 - Eye Irrit. 2

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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Consulter la Bibliothèque de documents

Pierre Clément et al.
The journal of sexual medicine, 9(10), 2562-2573 (2012-08-22)
A brain network specifically activated when ejaculation occurs has been described in rats. Increasing serotonin (5-hydroxytryptamine [5-HT]) tone impairs ejaculation and chronic 5-HT selective serotonin reuptake inhibitors (SSRIs) are known to inhibit ejaculation. However, efficacy of acute treatment with SSRI
Tae Kon Kim et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 926, 42-46 (2013-04-02)
In this study, we describe and validate a rapid and sensitive method for quantitation of dapoxetine in rat plasma by using ultra-performance liquid chromatography-electrospray ionization tandem mass spectrometry (UPLC-ESI/MS/MS). Plasma samples were prepared by protein precipitation with acetonitrile, and sildenafil
Stanley E Althof et al.
The journal of sexual medicine, 7(6), 2243-2252 (2010-04-07)
The Clinical Global Impression of Change (CGIC) measures have high utility in clinical practice. However, it is unknown whether the CGIC is valued for assessing premature ejaculation (PE) symptoms and/or the relationship between CGIC and other validated PE patient-reported measures.
Dapoxetine: a new option in the medical management of premature ejaculation
McMahon CG
Therapeutic Advances in Urology, 4(5), 233-251 (2012)
Hartmut Porst et al.
The journal of sexual medicine, 7(6), 2231-2242 (2010-04-24)
Premature ejaculation (PE) is classified as an acquired or lifelong condition but data on baseline characteristics and response to treatment of men with acquired or lifelong PE and mild erectile dysfunction (ED) or normal erectile function (EF) is limited. To
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