C5851

CGP 35348 hydrate

≥97% (NMR), solid

• Synonyme(s) : (3-Aminopropyl)(diethoxymethyl)phosphinic acid hydrate
• Formule empirique (notation de Hill): C₈H₂₀NO₄P · xH₂O
• Numéro CAS: 123690-79-9
• Poids moléculaire : 225.22 (anhydrous basis)
• Numéro MDL: MFCD11045877
• Code UNSPSC : 12352200
• ID de substance PubChem : 329775103
• Nomenclature NACRES : NA.77

Propriétés

• Pureté: ≥97% (NMR)
• Forme: solid
• Conditions de stockage: desiccated
• Couleur: white
• Solubilité: H₂O: >20 mg/mL
• Auteur: Novartis
• Température de stockage: −20°C
• Chaîne SMILES: O.CCOC(OCC)P(O)(=O)CCCN
• InChI: 1S/C8H20NO4P.H2O/c1-3-12-8(13-4-2)14(10,11)7-5-6-9;/h8H,3-7,9H2,1-2H3,(H,10,11);1H2
• Clé InChI: SRBHGEXMDCJOMS-UHFFFAOYSA-N

Description

Application

CGP 35348 hydrate has been used as a γ-aminobutyric acid-B (GABA_B) receptor inhibitor:

• to study its effects on intrinsic optical signal (IOS) in rat hippocampus
• alone or in combination with sodium salicylate to study its effects on auditory responses in the rat′s dorsal cortex of rat
• to study its effects on hepatocellular carcinoma cells (HCC)

Actions biochimiques/physiologiques

CGP 35348 is a γ-aminobutyric acid-B (GABA_B) receptor antagonist. It has a higher affinity towards post-versus presynaptic receptors that can penetrate the blood-brain barrier.

Caractéristiques et avantages

This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is featured on the GABAB Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by Novartis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Attention

Product is hygroscopic

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• Équipement de protection individuelle: Eyeshields, Gloves, type N95 (US)