C2806

Calcitonin Gene Related Peptide Fragment 8-37 human

≥97% (HPLC), powder

• Synonyme(s) : α-CGRP 8-37, FBHuman
• Formule empirique (notation de Hill): C₁₃₉H₂₃₀N₄₄O₃₈
• Numéro CAS: 119911-68-1
• Poids moléculaire : 3125.59
• Numéro MDL: MFCD00133153
• Code UNSPSC : 51111800
• ID de substance PubChem : 329774752
• Nomenclature NACRES : NA.32

Propriétés

• Niveau de qualité: 200
• Pureté: ≥97% (HPLC)
• Forme: powder
• Composition: Peptide content, ~70%
• Numéro d'accès UniProt: P06881; P01258
• Température de stockage: −20°C
• Chaîne SMILES: CC(C)C[C@H](NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H](NC(=O)[C@@H](N)C(C)C)[C@@H](C)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CO)C(=O)NCC(=O)NCC(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](C(C)C)C(=O)N3CCC[C@H]3C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc4ccccc4)C(N)=O
• InChI: 1S/C139H230N44O38/c1-66(2)48-86(161-102(193)60-155-113(197)74(17)159-120(204)87(49-67(3)4)168-118(202)83(40-31-45-152-138(147)148)163-123(207)90(53-80-57-151-65-158-80)173-136(220)111(77(20)188)182-131(215)105(145)69(7)8)121(205)169-88(50-68(5)6)122(206)176-96(64-186)129(213)165-84(41-32-46-153-139(149)150)119(203)175-94(62-184)115(199)156-58-101(192)154-59-104(195)177-107(71(11)12)134(218)179-108(72(13)14)133(217)166-82(39-28-30-44-141)117(201)171-91(54-98(142)189)125(209)172-92(55-99(143)190)124(208)170-89(52-79-36-25-22-26-37-79)126(210)180-109(73(15)16)137(221)183-47-33-42-97(183)130(214)181-110(76(19)187)135(219)174-93(56-100(144)191)127(211)178-106(70(9)10)132(216)157-61-103(194)162-95(63-185)128(212)164-81(38-27-29-43-140)116(200)160-75(18)114(198)167-85(112(146)196)51-78-34-23-21-24-35-78/h21-26,34-37,57,65-77,81-97,105-111,184-188H,27-33,38-56,58-64,140-141,145H2,1-20H3,(H2,142,189)(H2,143,190)(H2,144,191)(H2,146,196)(H,151,158)(H,154,192)(H,155,197)(H,156,199)(H,157,216)(H,159,204)(H,160,200)(H,161,193)(H,162,194)(H,163,207)(H,164,212)(H,165,213)(H,166,217)(H,167,198)(H,168,202)(H,169,205)(H,170,208)(H,171,201)(H,172,209)(H,173,220)(H,174,219)(H,175,203)(H,176,206)(H,177,195)(H,178,211)(H,179,218)(H,180,210)(H,181,214)(H,182,215)(H4,147,148,152)(H4,149,150,153)/t74-,75-,76+,77+,81-,82-,83-,84-,85-,86-,87-,88-,89-,90-,91-,92-,93-,94-,95-,96-,97-,105-,106-,107-,108-,109-,110-,111-/m0/s1
• Clé InChI: NDACAFBDTQIYCQ-YVQXRMNASA-N
• Informations sur le gène: human ... CALCA(796)

Description

Amino Acid Sequence

Val-Thr-His-Arg-Leu-Ala-Gly-Leu-Leu-Ser-Arg-Ser-Gly-Gly-Val-Val-Lys-Asn-Asn-Phe-Val-Pro-Thr-Asn-Val-Gly-Ser-Lys-Ala-Phe-NH2

Description générale

Calcitonin-related peptide α (CALCA) is a 37-amino-acid vasoactive neuropeptide. It is scattered in the central and peripheral nervous systems. The calcitonin/calcitonin gene-related peptide gene complex codes for a small family of peptides: calcitonin, katacalcin and CALCA. This vasodilator is potent than other vasodilators, such as adenosine, substance P or acetylcholine. CALCA gene is located on human chromosome 11p15.2-p15.1. Procalcitonin (PCT) is a calcitonin (CT) precursor.

Application

Calcitonin Gene Related Peptide Fragment 8-37 human has been used in the administration of drugs. It has been used to test the hypothesis that calcitonin gene‐related peptide (CGRP) plays a role in the fetal cardiovascular and metabolic defense responses to acute hypoxaemia by affecting sympathetic outflow.

Actions biochimiques/physiologiques

Selective competitive antagonist at CGRP receptors, but not at calcitonin receptors.
Calcitonin gene-related peptide (CALCA) serves as a proangiogenic growth factor in the development of human placenta. Mutations of CALCA gene is associated with Parkinson′s disease, ovarian cancer and essential hypertension. CALCA induce vascular endothelial cell proliferation, migration and capillary-like tube formation.

Autres remarques

Lyophilized from 0.1% TFA in H2O

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• Équipement de protection individuelle: Eyeshields, Gloves, type N95 (US)