C0869

Celastrol

≥98% (HPLC), solid, antioxidant

• Synonyme(s) : 10-Hydroxy-2,4a,6a,9,12b,14a-hexamethyl-11-oxo-1,2,3,4,4a,5,6,6a,11,12b,13,14,14a,14b-tetradecahydro-picene-2-carboxylic acid, Tripterin
• Formule empirique (notation de Hill): C₂₉H₃₈O₄
• Numéro CAS: 34157-83-0
• Poids moléculaire : 450.61
• Numéro MDL: MFCD03424073
• Code UNSPSC : 12352200
• ID de substance PubChem : 329774823
• Nomenclature NACRES : NA.77

Propriétés

• product name: Celastrol, ≥98% (HPLC), solid
• Pureté: ≥98% (HPLC)
• Forme: solid
• Couleur: red
• Solubilité: DMSO: >10 mg/mL; H₂O: insoluble
• Température de stockage: −20°C
• Chaîne SMILES: CC1=C(O)C(=O)C=C2C1=CC=C3[C@@]2(C)CC[C@@]4(C)[C@@H]5C[C@@](C)(CC[C@]5(C)CC[C@]34C)C(O)=O
• InChI: 1S/C29H38O4/c1-17-18-7-8-21-27(4,19(18)15-20(30)23(17)31)12-14-29(6)22-16-26(3,24(32)33)10-9-25(22,2)11-13-28(21,29)5/h7-8,15,22,31H,9-14,16H2,1-6H3,(H,32,33)/t22-,25-,26-,27+,28-,29+/m1/s1
• Clé InChI: KQJSQWZMSAGSHN-JJWQIEBTSA-N

Description

Application

Celastrol has been:

• used intraperitoneally to inject into experimental mice to study its role in nonalcoholic fatty liver disease (NAFLD)
• used in culture medium to study its effect on lipopolysaccharide-induced inflammatory injury in human keratinocyte cell culture
• used to study its effect in vitro and in vivo in VCaP cells

Actions biochimiques/physiologiques

Celastrol is a potent antioxidant, and anti-inflammatory agent. It is a novel HSP90 inhibitor (disrupts Hsp90/Cdc37 complex), that exhibits anticancer (anti-angiogenic - suppresses VEGFR expression); antioxidant (inhibits lipid peroxidation) and anti-inflammatory activity (suppresses iNOS and inflammatory cytokine production).

Celastrol is a quinone methide triterpene naturally present in Tripterygium wilfordii. It is useful in treating rheumatoid arthritis. Celastrol prevents the action of proteasome and nuclear factor Κb.

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 2
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• Équipement de protection individuelle: Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges