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A1500000

Azathioprine

European Pharmacopoeia (EP) Reference Standard

Synonyme(s) :

6-(1-Methyl-4-nitroimidazol-5-yl)thiopurine

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About This Item

Formule empirique (notation de Hill):
C9H7N7O2S
Numéro CAS:
446-86-6
Poids moléculaire :
277.26
Numéro MDL:
MFCD00069203
Code UNSPSC :
41116107
ID de substance PubChem :
329770711
Nomenclature NACRES :
NA.24

Qualité

pharmaceutical primary standard

Famille d'API

azathioprine

Fabricant/nom de marque

EDQM

Application(s)

pharmaceutical (small molecule)

Format

neat

Température de stockage

2-8°C

Chaîne SMILES 

Cn1cnc(c1Sc2ncnc3[nH]cnc23)[N+]([O-])=O

InChI

1S/C9H7N7O2S/c1-15-4-14-7(16(17)18)9(15)19-8-5-6(11-2-10-5)12-3-13-8/h2-4H,1H3,(H,10,11,12,13)

Clé InChI

LMEKQMALGUDUQG-UHFFFAOYSA-N

Informations sur le gène

human ... PPAT(5471)

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Catégories apparentées

Description générale

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Azathioprine EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Conditionnement

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Autres remarques

Sales restrictions may apply.

Produit(s) apparenté(s)

Réf. du produit
Description
Tarif

Y0001240

Azathioprine impurity A, European Pharmacopoeia (EP) Reference Standard

Y0001246

Azathioprine impurity G, European Pharmacopoeia (EP) Reference Standard

1046001

Azathioprine, United States Pharmacopeia (USP) Reference Standard

1045993

Azathioprine Related Compound A, United States Pharmacopeia (USP) Reference Standard

1045938

Azathioprine Related Compound G, United States Pharmacopeia (USP) Reference Standard

BP026

Azathioprine, British Pharmacopoeia (BP) Reference Standard

BP965

5-Chloro-1-methyl-4-nitroimidazole, British Pharmacopoeia (BP) Reference Standard

BP815

Bis-(1,7-dihydro-6H-purine)-6,6,-disulfide, British Pharmacopoeia (BP) Reference Standard

PHR2841

Azathioprine Related Compound A

Pictogrammes

Health hazardExclamation mark
GHS08,GHS07

Mention d'avertissement

Danger

Classification des risques

Acute Tox. 4 Oral - Carc. 1B - Eye Irrit. 2 - Repr. 2 - Skin Irrit. 2 - STOT SE 3

Organes cibles

Respiratory system

Code de la classe de stockage

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

Classe de danger pour l'eau (WGK)

WGK 3

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Certificats d'analyse (COA)

Lot/Batch Number

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Consulter la Bibliothèque de documents

Eliza Prefontaine et al.
The Cochrane database of systematic reviews, (6)(6), CD000545-CD000545 (2010-06-18)
The results from controlled clinical trials investigating the efficacy of azathioprine and 6-mercaptopurine for the treatment of active Crohn's disease were conflicting and controversial. A meta-analysis was performed to assess the effectiveness of these drugs for the induction of remission
Anne Bourrier et al.
Current drug targets, 14(12), 1471-1479 (2013-04-12)
Azathioprine is an efficient maintenance treatment of IBD, able to maintain a complete clinical and anatomical remission in about one third of patients. However there are concerns regarding its long term tolerance, particularly myelosuppression and malignancy. Azathioprine is not required
Jeffrey J Bidinger et al.
Journal of the American Academy of Dermatology, 65(1), 184-191 (2011-04-19)
Azathioprine (AZA) hypersensitivity syndrome is a rare side effect that typically occurs early in the initiation of therapy and may include a cutaneous eruption. It is often under-recognized because it mimics infection or disease exacerbation. Until recently, the cutaneous findings
Mandy E Schram et al.
Archives of dermatology, 147(4), 474-488 (2011-04-13)
To summarize evidence regarding the effectiveness, efficacy, and safety of off-label azathioprine use in dermatology. We searched the MEDLINE (1950-2009), EMBASE (1980-2009), and CENTRAL (1996-2009) databases on October 9, 2009. The main search terms were azathioprine and its synonyms. No
Fernando Magro et al.
The American journal of gastroenterology, 109(7), 1026-1036 (2014-05-07)
Crohn's disease (CD) induces cumulative structural damage, initially characterized by a non-stenosing non-penetrating behavior (B1) with progression over time to a fibro-stenosing (B2) and/or penetrating phenotype (B3). Our aim was to assess the long-term evolution of disease behavior of CD
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