04573

Thiamine hydrochloride

tested according to Ph. Eur.

• Synonyme(s) : Thiamio hydrochloridum, Aneurine hydrochloride, Vitamin B₁ hydrochloride
• Formule empirique (notation de Hill): C₁₂H₁₇ClN₄OS · HCl
• Numéro CAS: 67-03-8
• Poids moléculaire : 337.27
• Numéro Beilstein : 3851771
• Numéro CE : 200-641-8
• Numéro MDL: MFCD00012780
• Code UNSPSC : 12352209
• eCl@ss : 34058006
• ID de substance PubChem : 329747946
• Nomenclature NACRES : NA.26

Propriétés

• Source biologique: synthetic
• Niveau de qualité: 200
• Agence: USP/NF; tested according to Ph. Eur.
• Pureté: 98.5-101.0% anhydrous basis
• Forme: solid
• Pf: 250 °C (dec.) (lit.)
• Solubilité: alcohol: soluble 1 gm in 100 ml (95%); alcohol: soluble 1 gm in 315 ml (Absolute); glycerol: soluble 1 gm in 18 ml; water: soluble 1 g/mL; benzene: insoluble; chloroform: insoluble; diethyl ether: insoluble; hexane: insoluble; methanol: very soluble; propylene glycol: soluble
• Température de stockage: 2-8°C
• Chaîne SMILES: CC1=NC(N)=C(C[N+]2=CSC(CCO)=C2C)C=N1.Cl.[Cl-]
• InChI: 1S/C12H17N4OS.2ClH/c1-8-11(3-4-17)18-7-16(8)6-10-5-14-9(2)15-12(10)13;;/h5,7,17H,3-4,6H2,1-2H3,(H2,13,14,15);2*1H/q+1;;/p-1
• Clé InChI: DPJRMOMPQZCRJU-UHFFFAOYSA-M

Description

Application

Thiamine hydrochloride has been used as a keratin salts medium supplement for culturing log-phase fungus. It has also been used as a supplement of VB medium the minimal medium of Vogel and Bonner.

Actions biochimiques/physiologiques

Thiamine hydrochloride is a cheap, non-toxic and efficient catalyst for the synthesis of amidoalkyl naphthols. It inhibits the production of shikonin derivatives by suspension cultures of Lithospermum erythrorhizon. Additionally, thiamine hydrochloride addition to apple juice concentrates reduces its patulin content.

Thiamine hydrochloride is a hydrochloride salt form of thiamine (Vitamin B₁). It is crucial for aerobic metabolism, cell growth, transmission of nerve impulses and acetylcholine synthesis.

Informations sur la sécurité

• Pictogrammes: GHS07
• Mention d'avertissement: Warning
• Mentions de danger: H319
• Conseils de prudence: P264 - P280 - P305 + P351 + P338 - P337 + P313
• Classification des risques: Eye Irrit. 2
• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 1
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• Équipement de protection individuelle: Eyeshields, Gloves, type N95 (US)