RMNPMAG-83K
MILLIPLEX® Rat/Mouse Neuropeptide Magnetic Bead Panel - Neuroscience Multiplex Assay
The analytes available for this multiplex kit are: α-MSH, β-Endorphin, Neurotensin, Oxytocin, Substance P.
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About This Item
Code UNSPSC :
12161503
eCl@ss :
32161000
Nomenclature NACRES :
NA.84
Produits recommandés
Niveau de qualité
Espèces réactives
mouse, rat
Fabricant/nom de marque
Milliplex®
assay range
accuracy: 107-135%
(Rat)
standard curve range: 14-100,000 pg/mL
(Oxytocin)
standard curve range: 27-20,000 pg/mL
(Neurotensin)
standard curve range: 3-2,000 pg/mL
(Substance P)
standard curve range: 41-30,000 pg/mL
(α-MSH)
standard curve range: 69-50,000 pg/mL
(β-Endorphine)
Technique(s)
multiplexing: suitable
Méthode de détection
fluorometric (Luminex xMAP)
Conditions d'expédition
wet ice
Description générale
The MILLIPLEX® Rat/Mouse Neuropeptide Bead Panel, containing 5 biomarkers. This kit may be used for the analysis of all or any combination of the above analytes in tissue/cell lysate/culture supernatant samples and cerebrospinal fluid (CSF). Serum or plasma samples may also be used, and will need to be extracted, however we do not recommend using the panel for serum and plasma Substance P. The kit contains enough material to analyze 38 samples in duplicate, including the standard curve and two quality controls.
An important note about this panel is that the samples may be extracted using either the acetonitrile precipitation technique or the Waters 96-well HLB extraction plate. Please refer to the protocol for more information on both methods. The necessary components to perform the extractions are not included with the kit.
The central nervous system is a complex environment consisting of billions of neurons as well as glial support cells. These neurons use many different chemical signals to communicate information, including neurotransmitters, cannabinoids, peptides, and gases such as nitric oxide. Neuropeptides are secreted primarily from the central and peripheral nervous systems, exerting a broad spectrum of biological functions that includes the regulation of metabolism, reproduction, and immunity.
Panel Type: Neuroscience
An important note about this panel is that the samples may be extracted using either the acetonitrile precipitation technique or the Waters 96-well HLB extraction plate. Please refer to the protocol for more information on both methods. The necessary components to perform the extractions are not included with the kit.
The central nervous system is a complex environment consisting of billions of neurons as well as glial support cells. These neurons use many different chemical signals to communicate information, including neurotransmitters, cannabinoids, peptides, and gases such as nitric oxide. Neuropeptides are secreted primarily from the central and peripheral nervous systems, exerting a broad spectrum of biological functions that includes the regulation of metabolism, reproduction, and immunity.
Panel Type: Neuroscience
Application
- Analytes: α-MSH, β-Endorphin, Neurotensin, Oxytocin, Substance P.
- Recommended Sample type: serum, plasma, CSF, and tissue culture
- Recommended Sample dilution: This assay requires 50 μL extracted serum or plasma sample per well or 50 μL neat CSF or culture media per well
- Assay Run Time: Overnight
- NOTE: this is a competitive assay.
Caractéristiques et avantages
Design your multiplex kit by choosing available analytes within this panel.
Autres remarques
Sensitivity: Refer to kit protocol for sensitivities of individual biomarkers.
Informations légales
MILLIPLEX is a registered trademark of Merck KGaA, Darmstadt, Germany
Mention d'avertissement
Danger
Mentions de danger
Conseils de prudence
Classification des risques
Acute Tox. 3 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 2 - Skin Sens. 1
Code de la classe de stockage
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
Certificats d'analyse (COA)
Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".
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Retrouvez la documentation relative aux produits que vous avez récemment achetés dans la Bibliothèque de documents.
Willem J van den Brink et al.
British journal of pharmacology, 175(19), 3832-3843 (2018-07-28)
Because biological systems behave as networks, multi-biomarker approaches increasingly replace single biomarker approaches in drug development. To improve the mechanistic insights into CNS drug effects, a plasma neuroendocrine fingerprint was identified using multi-biomarker pharmacokinetic/pharmacodynamic (PK/PD) modelling. Short- and long-term D2
Willem J van den Brink et al.
The AAPS journal, 19(1), 274-285 (2016-10-28)
To reveal unknown and potentially important mechanisms of drug action, multi-biomarker discovery approaches are increasingly used. Time-course relationships between drug action and multi-biomarker profiles, however, are typically missing, while such relationships will provide increased insight in the underlying body processes.
Jen-Yin Goh et al.
Brain, behavior, and immunity, 89, 100-117 (2020-06-03)
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Nutrients, 11(10) (2019-10-09)
Iron deficiency anemia (IDA) is one of the most prevalent nutritional deficiencies worldwide. Iron plays critical roles in nervous system development and cognition. Despite the known detrimental consequences of IDA on cognition, available studies do not provide molecular mechanisms elucidating
Thiago B Kirsten et al.
Biology open, 8(5) (2019-05-01)
We have shown that exposure of rats to lipopolysaccharide (LPS) during gestation induces autistic-like behaviors in juvenile offspring and pioglitazone post treatment corrects social and communication deficits. The first objective of the present study was to evaluate the cognition of
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