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ABN1009

Sigma-Aldrich

Anti-TRPA1 Antibody

from rabbit, purified by affinity chromatography

Synonyme(s) :

Transient receptor potential cation channel subfamily A member 1, TRPA1, Ankyrin-like with transmembrane domains protein 1, Transformation-sensitive protein p120

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About This Item

Code UNSPSC :
12352203
eCl@ss :
32160702
Nomenclature NACRES :
NA.41

Source biologique

rabbit

Niveau de qualité

100

Forme d'anticorps

affinity isolated antibody

Type de produit anticorps

primary antibodies

Clone

polyclonal

Produit purifié par

affinity chromatography

Espèces réactives

rat, mouse, human

Technique(s)

immunohistochemistry: suitable
western blot: suitable

Numéro d'accès NCBI

NP_015628.2

Numéro d'accès UniProt

O75762

Conditions d'expédition

wet ice

Modification post-traductionnelle de la cible

unmodified

Informations sur le gène

human ... TRPA1(8989)

Description générale

Transient receptor potential A1 (also known as Transient receptor potential ankyrin 1) is an excitatory ion channel on primary sensory nerves of the pain pathway. It is encoded by the TRPA1/ANKTM1 gene in human (Trpa1/Anktm1 in rat & mouse) and plays a critical role in pain associated with tissue injury, inflammation, and nerve lesions. TRPA1 is reported to colocalize with PAR2 and coexpress with TRPV1 (Transient receptor potential vanilloid 1) in rat dorsal root ganglion (DRG) neurons. Agonist-induced TRPA1 current is shown to be enhanced upon PAR2 cleavage/activation by proinflammatory trypsin & tryptase (PMID 17571167). TRPA1 activation, in turn, is reported to result in enhanced TRPV1 phosphorylation and activity in a calcium- and PKA-dependent manner (PMID 24275229).

Immunogène

KLH-conjugated linear peptide corresponding to the cytoplasmic domain of human TRPA1.

Application

Anti-TRPA1 Antibody is an antibody against TRPA1 for use inWestern Blotting and Immunohistochemistry.
Immunohistochemistry Analysis: A 1:50-1,000 dilution from a representative lot detected TRPA1 in rat cerebellum, rat hindbrain, and rat pancreas tissue.

Qualité

Evaluated by Western Blotting in rat brain membrane tissue lysate.

Western Blotting Analysis: 0.1 µg/mL of this antibody detected TRPA1 in 10 µg of rat brain membrane tissue lysate.

Description de la cible

~130 kDa observed. Uncharacterized band(s) may appear in some lysates.

Autres remarques

Concentration: Please refer to lot specific datasheet.

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Code de la classe de stockage

12 - Non Combustible Liquids

Classe de danger pour l'eau (WGK)

WGK 1

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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Consulter la Bibliothèque de documents

Tomás S Huerta et al.
Journal of neural engineering, 20(2) (2023-03-16)
Objective.Sensory nerves of the peripheral nervous system (PNS) transmit afferent signals from the body to the brain. These peripheral nerves are composed of distinct subsets of fibers and associated cell bodies, which reside in peripheral ganglia distributed throughout the viscera
Frontiers in neurology and neuroscience research null
Xiangchen Kong et al.
Molecular metabolism, 29, 1-11 (2019-11-02)
Roux-en-Y gastric bypass surgery (RYGB) improves the first phase of glucose-stimulated insulin secretion (GSIS) in patients with type 2 diabetes. How it does so remains unclear. Farnesoid X receptor (FXR), the nuclear receptor of bile acids (BAs), is implicated in
Min Xia et al.
Frontiers in molecular neuroscience, 12, 98-98 (2019-05-07)
Intracerebral hemorrhage (ICH) is a devastating disease that is characterized by high morbidity and high mortality. ICH has an annual incidence of 10-30/100,000 people and accounts for approximately 10%-30% of all types of stroke. ICH mostly occurs at the basal
Daniel G Blackmore et al.
Molecular psychiatry, 26(11), 6975-6991 (2021-05-28)
Advanced physiological aging is associated with impaired cognitive performance and the inability to induce long-term potentiation (LTP), an electrophysiological correlate of memory. Here, we demonstrate in the physiologically aged, senescent mouse brain that scanning ultrasound combined with microbubbles (SUS+MB), by

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