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Key Documents

574714

Sigma-Aldrich

BAY 61-3606

≥97% (HPLC), solid, Syk inhibitor, Calbiochem®

Synonyme(s) :

Syk Inhibitor IV, BAY 61-3606, 2-(7-(3,4-Dimethoxyphenyl)-imidazo[1,2-c]pyrimidin-5-ylamino)-nicotinamide, HCl, BAY 61-3606

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About This Item

Formule empirique (notation de Hill):
C20H18N6O3 · xHCl · yH2O
Numéro CAS:
732983-37-8
Poids moléculaire :
390.40 (anhydrous free base basis)
Code UNSPSC :
12352200
Nomenclature NACRES :
NA.77

product name

Syk Inhibitor IV, BAY 61-3606, The Syk Inhibitor IV, BAY 61-3606, also referenced under CAS 732938-37-8, controls the biological activity of Syk. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

Niveau de qualité

100

Pureté

≥97% (HPLC)

Forme

solid

Puissance

10 nM IC50

Fabricant/nom de marque

Calbiochem®

Conditions de stockage

OK to freeze
desiccated (hygroscopic)
protect from light

Couleur

yellow

Solubilité

DMSO: 10 mg/mL
water: 20 mg/mL

Conditions d'expédition

ambient

Température de stockage

2-8°C

InChI

1S/C20H18N6O3/c1-28-15-6-5-12(10-16(15)29-2)14-11-17-22-8-9-26(17)20(24-14)25-19-13(18(21)27)4-3-7-23-19/h3-11H,1-2H3,(H2,21,27)(H,23,24,25)

Clé InChI

JWQOJVOKBAAAAR-UHFFFAOYSA-N

Description générale

A cell-permeable imidazopyrimidine compound that acts a potent, ATP-competitive, reversible, and highly selective inhibitor of Syk tyrosine kinase activity (IC50 = 10 nM) with no inhibitory effect against Btk, Fyn, Itk, Lyn, and Src even at concentrations as high as 4.7 µM. Shown to inhibit Syk-mediated cellular functions in vitro and exhibit good oral bioavailability and in vivo effacacy in the treatment of various allgery and asthma conditions in rat models.

Actions biochimiques/physiologiques

Cell permeable: yes
Primary Target
Syk
Product competes with ATP.
Reversible: yes

Conditionnement

Packaged under inert gas

Avertissement

Toxicity: Standard Handling (A)

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Autres remarques

Yamamoto, N., et al. 2003. J. Pharm. Exp. Ther.306, 1174.

Informations légales

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 2

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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Haruka Miki et al.
Journal of immunology (Baltimore, Md. : 1950), 204(4), 753-762 (2020-01-05)
House dust mite (HDM) allergens are leading causes of allergic asthma characterized by Th2 responses. The lung-resident CD11b+ dendritic cells (DCs) play a key role in Th2 cell development in HDM-induced allergic asthma. However, the regulatory mechanism of HDM-induced CD11b+
Ilaria Frasson et al.
Journal of molecular cell biology, 16(3) (2024-02-02)
The high mutation rate of SARS-CoV-2 leads to the emergence of multiple variants, some of which are resistant to vaccines and drugs targeting viral elements. Targeting host dependency factors, e.g. cellular proteins required for viral replication, would help prevent the
Sinu P John et al.
Cell reports, 41(1), 111441-111441 (2022-10-01)
Biologically active small molecules can impart modulatory effects, in some cases providing extended long-term memory. In a screen of biologically active small molecules for regulators of tumor necrosis factor (TNF) induction, we identify several compounds with the ability to induce
Ei'ichi Iizasa et al.
Nature communications, 12(1), 2299-2299 (2021-04-18)
Mycobacterial cell-wall glycolipids elicit an anti-mycobacterial immune response via FcRγ-associated C-type lectin receptors, including Mincle, and caspase-recruitment domain family member 9 (CARD9). Additionally, mycobacteria harbor immuno-evasive cell-wall lipids associated with virulence and latency; however, a mechanism of action is unclear.
Rohan P Choraghe et al.
Journal of cell science, 133(5) (2020-01-23)
Dendritic cell-associated C-type lectin 1 (Dectin-1, also known as CLEC7A) is an innate immune pattern recognition receptor that recognizes β-glucan on the Candida albicans cell wall. Recognition of β-glucan by immune cells leads to phagocytosis, oxidative burst, cytokine and chemokine
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