324732

ErbB2 Inhibitor II

The ErbB2 Inhibitor II, also referenced under CAS 928207-02-7, controls the biological activity of ErbB2. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

• Synonyme(s) : ErbB2 Inhibitor II, 4-(3-Phenoxyphenyl)-5-cyano-2H-1,2,3-triazole
• Formule empirique (notation de Hill): C₁₅H₁₀N₄O
• Numéro CAS: 928207-02-7
• Poids moléculaire : 262.27
• Code UNSPSC : 12352200
• Nomenclature NACRES : NA.77

Propriétés

• Niveau de qualité: 100
• Pureté: ≥95% (HPLC)
• Forme: solid
• Fabricant/nom de marque: Calbiochem^®
• Conditions de stockage: OK to freeze; protect from light
• Couleur: yellow
• Solubilité: DMSO: 50 mg/mL
• Conditions d'expédition: ambient
• Température de stockage: 2-8°C

Description

Description générale

A cell-permeable triazole compound that targets the ATP-binding site of erbB2/HER2 and reduces the phosphorylation of erbB2 in MDA-MB-453 cells (IC₅₀ = 6.6 µM), but not that of the overexpressed erbB1 in MDA-MB-468 cells even at concentrations as high as 100 µM. Shown to suppress MDA-MB-453 growth with an IC₅₀ of 30.9 µM.

Conditionnement

Packaged under inert gas

Avertissement

Toxicity: Irritant (B)

Reconstitution

Following reconstitution, aliquot and freeze (-20°). Stock solutions are stable for up to 3 months at -20°C.

Autres remarques

Cheng, Z. Y., et al. 2007. Bioorg. Med. Chem.15, 1533.

Informations légales

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3