300270

PARP Inhibitor III, DPQ

The PARP Inhibitor III, DPQ, also referenced under CAS 129075-73-6, controls the biological activity of PARP. This small molecule/inhibitor is primarily used for Cell Structure applications.

• Synonyme(s) : PARP Inhibitor III, DPQ, 3,4-Dihydro-5[4-(1-piperindinyl)butoxy]-1(2H)-isoquinoline
• Formule empirique (notation de Hill): C₁₈H₂₆N₂O₂
• Numéro CAS: 129075-73-6
• Poids moléculaire : 302.41
• Numéro MDL: MFCD01866274
• Code UNSPSC : 12352200
• Nomenclature NACRES : NA.77

Propriétés

• Niveau de qualité: 100
• Pureté: ≥90% (HPLC)
• Forme: solid
• Puissance: 40 nM IC₅₀
• Fabricant/nom de marque: Calbiochem^®
• Conditions de stockage: OK to freeze
• Couleur: off-white
• Solubilité: DMSO: 5 mg/mL
• Conditions d'expédition: ambient
• Température de stockage: −20°C
• InChI: 1S/C18H26N2O2/c21-18-16-7-6-8-17(15(16)9-10-19-18)22-14-5-4-13-20-11-2-1-3-12-20/h6-8H,1-5,9-14H2,(H,19,21)
• Clé InChI: RVOUDNBEIXGHJY-UHFFFAOYSA-N

Description

Description générale

A potent and selective inhibitor of poly(ADP-ribose) polymerase (PARP; IC₅₀ = 40 nM). Significantly reduces infarcet volume in rat focual cerebrale ischemia model.

A very potent and selective poly(ADP-ribose)polymerase (PARP) inhibitor (IC₅₀ = 40 nM). Significantly reduces infarcet volume in rat focual cerebrale ischemia model.

Actions biochimiques/physiologiques

Cell permeable: no

Product does not compete with ATP.

Reversible: no

Avertissement

Toxicity: Harmful (C)

Autres remarques

Eliasson, M.J., et al. 1997. Nat. Med. 3, 1089.
Takahashi, K., et al. 1997. J. Cereb. Blood Flow Metabl. 17, 1137.
Suto, M.J., et al. 1991. Anticancer Drug Des. 6, 107.

Informations légales

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3