902543

Propargyl-PEG4-acid

• Synonyme(s) : 4,7,10,13-Tetraoxahexadec-15-ynoic acid, Propargyl-PEG4-CH₂CO₂H
• Formule empirique (notation de Hill): C₁₂H₂₀O₆
• Numéro CAS: 1415800-32-6
• Poids moléculaire : 260.28
• Numéro MDL: MFCD22683284
• Code UNSPSC : 12352106
• Nomenclature NACRES : NA.22

Propriétés

• Forme: liquid
• Pertinence de la réaction: reagent type: linker
• Disponibilité: available only in USA
• Indice de réfraction: n/D 1.460
• Densité: 1.164 g/mL
• Groupe fonctionnel: alkyne; carboxylic acid
• Température de stockage: −20°C
• Chaîne SMILES: OC(CCOCCOCCOCCOCC#C)=O

Description

Application

This heterobifunctional, PEGylated crosslinker features a carboxylic acid at one end and propargyl group at the other for reaction with azide-containing compounds using click chemistry. The hydrophillic PEG linker facilitates solubility in biological applications. Propargyl-PEG4-acid can be used for bioconjugation or as a building block for synthesis of small molecules, conjugates of small molecules and/or biomolecules, or other tool compounds for chemical biology and medicinal chemistry that require ligation. Examples of applications include its synthetic incorporation into antibody-drug conjugates or proteolysis-targeting chimeras (PROTAC^® molecules) for targeted protein degradation.

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Autres remarques

Design, Synthesis, and Evaluation of Novel 1,2,3-Triazole-Tethered Glycolipids as Vaccine Adjuvants

Informations légales

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

Informations sur la sécurité

• Pictogrammes: GHS02
• Mention d'avertissement: Danger
• Mentions de danger: H242
• Conseils de prudence: P210 - P234 - P235 - P240 - P370 + P378 - P403
• Classification des risques: Self-react. C
• Code de la classe de stockage: 5.2 - Organic peroxides and self-reacting hazardous materials
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable