764248

Amino-PEG4-alkyne

• Synonyme(s) : 3,6,9,12-Tetraoxapentadec-14-yn-1-amine, Acetylene-PEG4-amine, H₂N-PEG4-propyne, Triethylene glycol 2-aminoethyl propargyl ether
• Formule empirique (notation de Hill): C₁₁H₂₁NO₄
• Numéro CAS: 1013921-36-2
• Poids moléculaire : 231.29
• Numéro MDL: MFCD22380736
• Code UNSPSC : 12352106
• ID de substance PubChem : 329767109
• Nomenclature NACRES : NA.22

Propriétés

• Forme: liquid
• Capacité de réaction: reaction type: click chemistry
• Pertinence de la réaction: reagent type: cross-linking reagent
• Groupe fonctionnel: alkyne; amine
• Température de stockage: −20°C
• Chaîne SMILES: NCCOCCOCCOCCOCC#C
• InChI: 1S/C11H21NO4/c1-2-4-13-6-8-15-10-11-16-9-7-14-5-3-12/h1H,3-12H2
• Clé InChI: QDLPAHLHHBCWOW-UHFFFAOYSA-N

Description

Application

Heterobifunctional linker enabling the connection of an azide containing compound or biomolecule to one with a carboxylic acid. The amine group can be linked to a carboxylic acid through standard coupling procedures (EDC, product #39391, etc...) and the terminal alkyne will react with azides via copper-catalyzed 1,3-dipolar cycloaddition click chemistry. The hydrophilic PEG spacer adds to the water solubility of this reagent, allowing for easy modification of carboxylic acid containing biomolecules such as antibodies, proteins and peptides with the terminal alkyne. The PEG spacer also reduces aggregation of modified proteins stored in solution by adding hydrophilic character.

Amino-PEG4-alkyne may be used to synthesize alkynyl-functionalized iron oxide nanoparticles (IONPs) for preparing glycopolymer-based iron oxide nanoparticles (GIONs) for potential bioscience applications.

Informations sur la sécurité

• Code de la classe de stockage: 10 - Combustible liquids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable