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119660

Sigma-Aldrich

Tris(2-chloroethyl) phosphate

97%

Synonyme(s) :

Phosphoric acid tris(2-chloroethyl) ester

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About This Item

Formule linéaire :
(ClCH2CH2O)3P(O)
Numéro CAS:
115-96-8
Poids moléculaire :
285.49
Numéro CE :
204-118-5
Numéro MDL:
MFCD00000967
Code UNSPSC :
12352100
ID de substance PubChem :
24847295
Nomenclature NACRES :
NA.22

Pression de vapeur

<10 mmHg ( 25 °C)

Pureté

97%

Indice de réfraction

n20/D 1.472 (lit.)

Point d'ébullition

192 °C/10 mmHg (lit.)

Solubilité

H2O: soluble 7.82 g/L

Densité

1.39 g/mL at 25 °C (lit.)

Chaîne SMILES 

ClCCOP(=O)(OCCCl)OCCCl

InChI

1S/C6H12Cl3O4P/c7-1-4-11-14(10,12-5-2-8)13-6-3-9/h1-6H2

Clé InChI

HQUQLFOMPYWACS-UHFFFAOYSA-N

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Description générale

Tris(2-chloroethyl) phosphate is used as a flame retardant in plastics, especially inflexible foams used in automobiles and furniture and in rigid foams used for building insulation.

Application

Tris(2-chloroethyl) phosphate was used in dynamic air sampling of airborne organophosphate triesters using a solid-phase microextraction device.

Pictogrammes

Health hazardExclamation mark
GHS08,GHS07

Mention d'avertissement

Danger

Mentions de danger

H302,H351,H360

Classification des risques

Acute Tox. 4 Oral - Carc. 2 - Repr. 1B

Code de la classe de stockage

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

449.6 °F - closed cup

Point d'éclair (°C)

232 °C - closed cup

Équipement de protection individuelle

Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter

Certificats d'analyse (COA)

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K Dix et al.
Journal of pharmaceutical sciences, 83(11), 1622-1629 (1994-11-01)
The pharmacokinetics of tris(2-chloroethyl) phosphate (TRCP, 20 mg/kg, iv) were investigated in awake male and female and anesthetized male Fischer 344 (F344) rats by conventional (CONV) sampling/detection methods (blood withdrawal with sample workup and analysis for TRCP). TRCP pharmacokinetics were
M Sala et al.
European journal of cancer & clinical oncology, 18(12), 1337-1344 (1982-12-01)
Tris(2,3-dibromopropyl)phosphate (Tris-BP) and Tris(2-chloroethyl) orthophosphate (Genomoll P) were analyzed for mutagenic and carcinogenic activity in several in vitro and in vivo mammalian systems. In the in vitro tests both Tris-BP and Genomoll P increased sister chromatid exchanges in V79 cells
Jennifer Jackson et al.
The Science of the total environment, 405(1-3), 153-160 (2008-08-08)
Synthetic endocrine-disrupting chemicals (EDCs) have been found in surface waters throughout the United States, and are known to enter waterways via discharge from wastewater treatment plants (WWTPs). Studies addressing EDCs in wastewater do not examine their specific sources upstream of
Xianghao Ren et al.
Journal of water and health, 10(4), 522-530 (2012-11-21)
Being a typical micropollutant, tris-(2-chloroethyl)-phosphate (TCEP) is often found in aquatic environments. However, the potential effects of TCEP at environmental concentrations on apoptotic mechanisms are mostly unknown. Thus, the purpose of this study is to investigate the apoptotic regulatory protein
H A Tilson et al.
Toxicology and applied pharmacology, 106(2), 254-269 (1990-11-01)
Adult female, Fischer-344 rats were exposed to 275 mg/kg of tris(2-chloroethyl)phosphate (TRCP) by gavage. TRCP produced consistent signs of convulsive activity within 60-90 min after dosing and extensive loss of CAT hippocampal pyramidal cells when examined 7 days after dosing.
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