Understanding trans platinum complexes as potential antitumor drugs beyond targeting DNA.

Understanding trans platinum complexes as potential antitumor drugs beyond targeting DNA.

Journal of inorganic biochemistry (2012-07-24)

A G Quiroga

PMID22819649

ABSTRACT

This focused review is devoted to our advances in developing trans platinum complexes as antitumoral complexes, in particular those bearing aliphatic amines. It includes some fundamental aspects of the understanding of non conventional metallodrug mechanism. The perspective is arranged by those fundamental aspects and within each section only the most successful examples have been included and also those in which clearly SAR's (structure activity relationships) have been observed.

MATERIALS

Product Number

Brand

Product Description

685453

Sigma-Aldrich

Platinum, nanopowder, <50 nm particle size (TEM)

204048

Sigma-Aldrich

Platinum, powder (coarse), 99.99% trace metals basis

357359

Sigma-Aldrich

Platinum, wire, diam. 0.20 mm, ≥99.99% trace metals basis

303798

Sigma-Aldrich

Platinum, foil, thickness 0.05 mm, ≥99.9% trace metals basis

298107

Sigma-Aldrich

Platinum, gauze, 52 mesh, 99.9% trace metals basis

373214

Sigma-Aldrich

Platinum, evaporation slug, diam. × L 0.6 cm × 1.2 cm, 99.99% trace metals basis

267201

Sigma-Aldrich

Platinum, wire, diam. 0.5 mm, 99.99% trace metals basis

327433

Sigma-Aldrich

Platinum, foil, thickness 0.125-0.135 mm, 99.9% trace metals basis

267228

Sigma-Aldrich

Platinum, wire, diam. 0.5 mm, 99.9% trace metals basis

357367

Sigma-Aldrich

Platinum, wire, diam. 0.10 mm, 99.99% trace metals basis

267163

Sigma-Aldrich

Platinum, wire, diam. 0.127 mm, 99.99% trace metals basis

267171

Sigma-Aldrich

Platinum, wire, diam. 0.25 mm, 99.99% trace metals basis

267155

Sigma-Aldrich

Platinum, sponge, ≥99.9% trace metals basis

327492

Sigma-Aldrich

Platinum, wire, diam. 1.0 mm, 99.9% trace metals basis

349356

Sigma-Aldrich

Platinum, foil, thickness 0.05 mm, 99.99% trace metals basis

349399

Sigma-Aldrich

Platinum, wire, diam. 1.5 mm, ≥99.9% trace metals basis

373265

Sigma-Aldrich

Platinum, wire, diam. 0.25 mm, thermocouple grade

349364

Sigma-Aldrich

Platinum, foil, thickness 0.025 mm, 99.99% trace metals basis

349372

Sigma-Aldrich

Platinum, foil, thickness 1.0 mm, 99.99% trace metals basis

267260

Sigma-Aldrich

Platinum, foil, thickness 0.5 mm, 99.99% trace metals basis

204013

Sigma-Aldrich

Platinum, powder, 99.995% trace metals basis

GF68919889

Platinum, foil, 15mm disks, thickness 0.0075mm, as rolled, 99.95%

GF22400345

Platinum, foil, 4mm disks, thickness 0.1mm, as rolled, 99.99+%

GF91411444

Platinum, foil, 0.2m coil, thickness 0.030mm, coil width .7mm, as rolled, 99.95%

GF78943674

Platinum, wire reel, 0.2m, diameter 0.25mm, as drawn, 99.998%

GF06852900

Platinum, wire reel, 0.2m, diameter 0.006mm, wollaston, 99.9%

GF59961594

Platinum, wire reel, 0.5m, diameter 0.05mm, annealed, may be used as one component of a thermocouple, 99.99%

GF94151257

Platinum, wire reel, 0.5m, diameter 0.25mm, as drawn, 99.998%

GF83518364

Platinum, wire reel, 0.2m, diameter 0.5mm, annealed, may be used as one component of a thermocouple, 99.99%

GF71917005

Platinum, foil, 0.1m coil, thickness 0.025mm, coil width 8mm, as rolled, 99.95%