Towards the prevention of potential aluminum toxic effects and an effective treatment for Alzheimer's disease.

Towards the prevention of potential aluminum toxic effects and an effective treatment for Alzheimer's disease.

Journal of inorganic biochemistry (2011-11-22)

Maire E Percy, Theo P A Kruck, Aileen I Pogue, Walter J Lukiw

PMID22099160

ABSTRACT

In 1991, treatment with low dose intramuscular desferrioxamine (DFO), a trivalent chelator that can remove excessive iron and/or aluminum from the body, was reported to slow the progression of Alzheimer's disease (AD) by a factor of two. Twenty years later this promising trial has not been followed up and why this treatment worked still is not clear. In this critical interdisciplinary review, we provide an overview of the complexities of AD and involvement of metal ions, and revisit the neglected DFO trial. We discuss research done by us and others that is helping to explain involvement of metal ion catalyzed production of reactive oxygen species in the pathogenesis of AD, and emerging strategies for inhibition of metal-ion toxicity. Highlighted are insights to be considered in the quests to prevent potentially toxic effects of aluminum toxicity and prevention and intervention in AD.

MATERIALS

Product Number

Brand

Product Description

326887

Sigma-Aldrich

Aluminum, wire, diam. 0.58 mm, ≥99.99% trace metals basis

326941

Sigma-Aldrich

Aluminum, pellets, 3-8 mesh, ≥99.999% trace metals basis

266558

Sigma-Aldrich

Aluminum, wire, diam. 1.0 mm, 99.999% trace metals basis

518573

Sigma-Aldrich

Aluminum, granular, <1 mm, 99.7% trace metals basis

IRMM523C

Aluminum, IRMM^®, certified reference material, 1.0 mm wire

IRMM523B

Aluminum, IRMM^®, certified reference material, 1.0 mm foil

11009

Sigma-Aldrich

Aluminum, powder, ≥91% (complexometric)

433705

Sigma-Aldrich

Aluminum, evaporation slug, diam. × L 6.3 mm × 6.3 mm, 99.999% trace metals basis

733369

Sigma-Aldrich

Aluminum, foil, thickness 8 μm, 99% trace metals basis

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Aluminum, sphere, 100pcs, diameter 1.0mm, aluminum alloy 2017 precision sphere, grade 200, 95.2%

GF68037723

Aluminum, wire reel, 1000m, diameter 0.30mm, as drawn, 99.5%

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Aluminum, wire reel, 100m, diameter 0.063mm, annealed, 99.99%

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Aluminum, sphere, 100pcs, diameter 2.5mm, aluminum alloy 2017 precision sphere, grade 200, 95.2%

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Aluminum, rod, 200mm, diameter 15.0mm, as drawn, 99.999%

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Aluminum, microleaf disks, 25mm, thinness 0.15μm, specific density 41.28μg/cm², removable support, 99.999%

GF53821234

Aluminum, mesh, 900x900mm, nominal aperture 0.38mm, wire diameter 0.25mm, 40x40 wires/inch, open area 37%, plain weave mesh

GF53651796

Aluminum, tube, 1000mm, outside diameter 1.42mm, inside diameter 1.166mm, wall thickness 0.127mm, as drawn, 99.5%

GF73255237

Aluminum, rod, 200mm, diameter 20.0mm, as drawn, 99.999%

GF95825403

Aluminum, sphere, 100pcs, diameter 3.0mm, aluminum alloy 2017 precision sphere, grade 200, 95.2%

GF93280732

Aluminum, rod, 500mm, diameter 15.0mm, as drawn, 99.999%

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Aluminum, rod, 100mm, diameter 28mm, as drawn, 99.999%

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Aluminum, microfoil, disks, 25mm, thinness 1.0μm, specific density 269.9μg/cm², permanent mylar 3.5μm support, 99.999%

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Aluminum, insulated wire, 2m, conductor diameter 0.1mm, insulation thickness 0.005mm, polyimide insulation, 99.95+%

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Aluminum, tube, 1000mm, outside diameter 0.86mm, inside diameter 0.76mm, wall thickness 0.05mm, as drawn, 99.5%

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Aluminum, rod, 200mm, diameter 5.0mm, as drawn, 99.999%

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Aluminum, tube, 500mm, outside diameter 3.0mm, inside diameter 1.62mm, wall thickness 0.69mm, hard, 99.5%

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Aluminum, tube, 200mm, outside diameter 0.30mm, inside diameter 0.2mm, wall thickness 0.05mm, as drawn, 99.5%

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Aluminum, wire reel, 100m, diameter 0.25mm, hard, 99.99+%

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Aluminum, rod, 200mm, diameter 12.0mm, as drawn, 99.999%

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Aluminum, wire reel, 100m, diameter 0.25mm, as drawn, 99.5%