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H-003

Supelco

Hydrocodone solution

1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®

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About This Item

Empirical Formula (Hill Notation):
C18H21NO3
CAS Number:
125-29-1
Molecular Weight:
299.36
UNSPSC Code:
41116107
NACRES:
NA.24

grade

certified reference material

Quality Level

300

form

liquid

feature

Snap-N-Spike®/Snap-N-Shoot®

packaging

ampule of 1 mL

manufacturer/tradename

Cerilliant®

drug control

Narcotic Licence Schedule A (Switzerland); estupefaciente (Spain); Decreto Lei 15/93: Tabela IA (Portugal)

concentration

1.0 mg/mL in methanol

technique(s)

gas chromatography (GC): suitable
liquid chromatography (LC): suitable

application(s)

forensics and toxicology

format

single component solution

storage temp.

−20°C

InChI

1S/C18H21NO3.C4H6O6.H2O/c1-19-8-7-18-11-4-5-13(20)17(18)22-16-14(21-2)6-3-10(15(16)18)9-12(11)19;5-1(3(7)8)2(6)4(9)10;/h3,6,11-12,17H,4-5,7-9H2,1-2H3;1-2,5-6H,(H,7,8)(H,9,10);1H2/t11-,12+,17-,18-;1-,2-;/m01./s1

InChI key

ZICRJLQTAUVSDU-NSJZFRMTSA-N

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General description

Hydrocodone is a semi-synthetic opioid derived from codeine or thebaine, two naturally-occurring opiates. The drug, also known as dihydrocodeinone, is used as an analgesic to treat pain and as an antitussive for coughing or related conditions. This Certified Spiking Solution® is suitable as a starting material for calibrators or controls in GC/MS or LC/MS testing applications from pharmaceutical research and pain prescription monitoring to clinical toxicology and forensic analysis.

Application


  • Hydrocodone Bitartrate ER: A Review in Chronic Pain.: This comprehensive review evaluates the extended-release formulation of hydrocodone, focusing on its pharmacological properties, therapeutic efficacy, and clinical applications in managing chronic pain, which underscores its significance in long-term pain management strategies (Dhillon S, 2016).

Recommended products

Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.

Legal Information

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany
CERTIFIED SPIKING SOLUTION is a registered trademark of Cerilliant Corporation
Snap-N-Shoot is a registered trademark of Cerilliant Corporation
Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany

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Hydrocodone-D3 solution, 100 μg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®

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Pain Management Multi-component Opiate Mixture-13 solution, 100 μg/mL each component (10 μg/mL Fentanyl), ampule of 1.0 mL, certified reference material, Cerilliant®

O-020

Opiate Multi-component Mixture-5 solution, 250 μg/mL each component in methanol, ampule of 1.0 mL, certified reference material, Cerilliant®

H-008

Hydrocodone-D3 solution, 1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®

H-047

Hydrocodone-D6 solution, 100 μg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®

H-048

Hydrocodone-D6 solution, 1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®

N-053

Norhydrocodone hydrochloride solution, 1.0 mg/mL in methanol (as free base), ampule of 1 mL, certified reference material, Cerilliant®

N-054

Norhydrocodone-d3 hydrochloride, 100 μg/mL in methanol (as free base), ampule of 1 mL, certified reference material, Cerilliant®

H-003S

Hydrocodone solution, 1 mg/mL in methanol, certified reference material, ampule of 1 mL, Cerilliant®

Signal Word

Danger

Hazard Classifications

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1

Target Organs

Eyes

Storage Class Code

3 - Flammable liquids

WGK

WGK 2

Flash Point(F)

49.5 °F - closed cup

Flash Point(C)

9.7 °C - closed cup

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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FDA committee: More restrictions needed on hydrocodone combination products.
Bridget M Kuehn
JAMA, 309(9), 862-862 (2013-03-07)
Elizabeth A Micks et al.
Obstetrics and gynecology, 120(5), 1060-1069 (2012-10-24)
Although hydrocodone-acetaminophen is commonly used for pain control in first-trimester abortion, the efficacy of oral opioids for decreasing pain has not been established. Our objective was to estimate the effect of hydrocodone-acetaminophen on patient pain perception during first-trimester surgical abortion.
FDA panel recommends tighter rules for prescribing opioids.
Michael McCarthy
BMJ (Clinical research ed.), 346, f1012-f1012 (2013-02-16)
William Edward Ackerman
The Journal of the Arkansas Medical Society, 109(5), 90-93 (2012-10-16)
Hydrocodone is frequently prescribed for moderate to severe pain. Nicotine has analgesic properties and it is hypothesized that cigarette smoking might decrease the dosage of hydrocodone needed for the relief of chronic pain. This would be a topic of importance
Kathryn P Anastassopoulos et al.
Journal of opioid management, 9(2), 97-109 (2013-05-28)
Pain is a prevalent condition that often involves a neuropathic component. Hydrocodone is one of the most widely used opioids for pain but is often associated with side effects (SEs). This study sought to characterize the experience of patients taking
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