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HomeAdvanced Gene EditingCRISPR Essentials: MISSION® CRISPR gRNAs, Cas9 and Related Products

CRISPR Essentials: MISSION® CRISPR gRNAs, Cas9 and Related Products

Compare and contrast the features of CRISPR ribonucleoprotein (RNP) products: guide RNA (gRNA) and Cas9 products for in vitro and in vivo CRISPR experiments including knockout/knock-in, activation, and inhibition. Select the best formats for your specific applications from synthetic gRNA, plasmid DNA, lentiviral particles, and proteins.

Section Overview


Single-guide Synthetic RNA

Synthetic CRISPR gRNAs with guaranteed activity

ProductDescriptionSpecifications AvailableProduct Availability
PURedit™ Synthetic gRNAChoose from our collection of predesigned guides optimized for knockout in human and mouse genomes or design and order custom sequences.
  • Purity >80%
  • Enhanced quality
  • Stabilizing modifications available
Ships in 7-10 business days
Standard Synthetic gRNAChoose from our collection of predesigned guides optimized for knockout in human and mouse genomes or design and order custom sequences.
  • Stabilizing modifications available
  • 3 nmol
  • SpCas9
Ships in 5-7 business days

Two-part Synthetic gRNA

ProductDescriptionSpecifications AvailableProduct Availability
Synthetic crRNAChoose from our collection of predesigned guides optimized for knockout in human and mouse genomes or design and order custom sequences.
  • HPLC or Desalt purification
  • Stabilizing modifications available
  • 2 and 5 nmol
  • Desalt ships in 3-5 business days
  • HPLC ships in 5-7 business days
TRACRRNA05NSynthetic SpCas9 tracrRNA
5 nmolReady to ship
TRACRRNAMODSynthetic SpCas9 modified tracrRNA
Pair with modified crRNA
5 nmolReady to ship

CRISPR two-part system requires both crRNA and tracrRNA to complex with Cas9.

Cas9 Proteins

Product No.ProductDescription/Application
PECAS9PURedit™ Cas9PURedit™ SpCas9 with enhanced quality and high efficiency. Engineered for high on-target activity without compromising in specificity. Ideal for preclinical and translational applications including cell-based therapies.
CAS9PLCas9 PlusHigh efficiency SpCas9 variant that gives both high on-target activity and specificity. Ideal for applications requiring high accuracy.
CAS9GFPPROWild-type SpCas9-EGFP Fusion
Original Wild-Type Cas9 fused to enhanced green fluorescent protein. Ideal for flow cytometry applications and visualization of transfected RNP complexes. Highly efficient
ECAS9GFPPR
Enhanced specificity SpCas9-EGFP Fusion
Cas9 variant with Improved specificity fused to enhanced green fluorescent protein. Ideal for flow cytometry applications, fluorescence microscopy and for experiments that require high accuracy
CAS9PROTWild-type SpCas9Original , wild-type Cas9; simple and economical; efficient in a broad range of gene editing applications
ESPCAS9PROEnhanced specificity SpCas9
Cas9 variant with improved specificity ideal for experiments that require high accuracy
CAS9D10APRCas9D10A NickaseA two-gRNA system with improved specificity and decreased off-target potential for specialized genome-editing applications
DCAS9PROTdCas9-3XFLAG™ BiotinCatalytically inactive SpCas9 protein containing a 3XFLAGTM tag and Biotin; ideal for DNA detection and isolation and is a component of the proxy-CRISPR method
FNCAS9PROTFnCas9 ProteinIdeal for synthetic biology or cell-free applications

Sanger QuickPick™ Knockout Pre-cloned Guides

ProductDescriptionProduct Availability
Sanger QuickPick™ Knockout Pre-cloned GuidesChoose ready-to-use guides from the Sanger Whole Genome Knockout Library for human and mouse, pre-cloned into the Sanger vector backbone.Ready to ship

Cas9 Products

Product No.DescriptionFormat
CAS9PSpCas9 plasmidPlasmid DNA
CAS9GFPPSpCas9 GFP PlasmidPlasmid DNA
CAS9RFPPSpCas9 RFP PlasmidPlasmid DNA
CAS9GEMPSpCas9 GFP Geminin PlasmidPlasmid DNA
CAS9D10APSpCas9-D10A Nickase PlasmidPlasmid DNA
CAS9D10AGFPPSpCas9-D10A Nickase GFP PlasmidPlasmid DNA
CAS9D10ARFPPSpCas9-D10A Nickase RFP PlasmidPlasmid DNA
DCAS9PSpdCas9 PlasmidPlasmid DNA
DCAS9P300SpdCas9-p300 Activator
Plasmid
Plasmid DNA
DCAS9P300RFPSpdCas9-p300 RFP Activator
Expression Plasmid
Plasmid DNA
FNCAS9PFnCas9 PlasmidPlasmid DNA
CAS9MRNASpCas9 mRNAmRNA
CAS9D10AMRNASpCas9-D10A Nickase mRNAmRNA
CAS9BSTSpCas9 Blasticidin Lenti PlasmidPlasmid DNA
CAS9HYGROVPSpCas9 Hygromycin Lenti PlasmidPlasmid DNA
CAS9NEOSpCas9 Neomycin Lenti PlasmidPlasmid DNA
CAS9ZEOVPSpCas9 Zeo Lenti PlasmidPlasmid DNA
CAS9GFPVPSpCas9 GFP Lenti PlasmidPlasmid DNA
CAS9RFPVPSpCas9 RFP Lenti PlasmidPlasmid DNA
ESPCAS9BSTHigh Fidelity Sp Cas9 Blasticidin Lenti PlasmidPlasmid DNA
LVCAS9BSTSpCas9 Blasticidin Lenti ParticlesLentivirus
LVCAS9NEOSpCas9 Neomycin Lenti ParticlesLentivirus
CAS9BAC1P
SpCas9 Lambda Red Homologous Recombination Plasmid for E.coli
Plasmid DNA
Product No.DescriptionCompatible gRNA vectorSystemFormatSelection MethodComment
SAMHELPERVSAM CRISPRa Helper Construct Kit Lentiviral Transduction ParticlesLV06 & LV07LentiviralLentivirusBlasticidin & HygromycinOrder compatible gRNA separately

Kit contains 2 components:
  • dCas9-VP64-Blasticidin SAM CRISPRa Helper Construct 1
  • MS2-P65-HSF1-Hygromycin SAM CRISPRa Helper Construct 2
SAMHELPERPSAM CRISPRa Helper Construct Kit Plasmid DNALV06 & LV07LentiviralPlasmid DNABlasticidin & HygromycinOrder compatible gRNA separately

Kit contains 2 components:
  • dCas9-VP64-Blasticidin SAM CRISPRa Helper Construct 1
  • MS2-P65-HSF1-Hygromycin SAM CRISPRa Helper Construct 2
SAMVP64BSTVdCas9-VP64-Blasticidin SAM CRISPRa Helper Construct 1 Lentiviral Transduction ParticlesLV06 & LV07LentiviralLentivirusBlasticidinOrder compatible gRNA separately

Requires MS2-P65-HSF1-Hygromycin SAM CRISPRa Helper Construct 2
SAMVP64BSTdCas9-VP64-Blasticidin SAM CRISPRa Helper Construct 1 Plasmid DNALV06 & LV07LentiviralPlasmid DNABlasticidinOrder compatible gRNA separately

Requires MS2-P65-HSF1-Hygromycin SAM CRISPRa Helper Construct 2
SAMMS2HYGVMS2-P65-HSF1-Hygromycin SAM CRISPRa Helper Construct 2 Lentiviral Transduction ParticlesLV06 & LV07LentiviralLentivirusHygromycinOrder compatible gRNA separately

Requires dCas9-VP64-Blasticidin SAM CRISPRa Helper Construct 1
SAMMS2HYGMS2-P65-HSF1-Hygromycin SAM CRISPRa Helper Construct 2 Plasmid DNALV06 & LV07LentiviralPlasmid DNAHygromycinOrder compatible gRNA separately

Requires dCas9-VP64-Blasticidin SAM CRISPRa Helper Construct 1
CRISPRICONCRISPRi Control & Effector KitLV17LentiviralLentivirusPuromycin & BFP
  • KRAB-dCas9 - Blasticidin CRISPRi Construct Lentiviral Transduction Particles
  • CRISPRi RAB1A Puromycin Control Transduction Particles
  • CRISPRi Nontargeting Control Puromycin Transduction Particles
CRISPRI10X10X CRISPRi Feature Barcode Optimization Kit  LV13 LV14 LV15 LV16  LentiviralLentivirusPuromycin & BFP
  • RAB1A And Nontargeting Control With 10x Capture Sequence 1 Stem-Loop Position
  • RAB1A And Nontargeting Control With 10x Capture Sequence 1 3 Prime Position
  • RAB1A And Nontargeting Control With 10x Capture Sequence 2 Stem-Loop Position
  • RAB1A And Nontargeting Control With 10x Capture Sequence 2 3 Prime Position

Negative Controls

Product No.DescriptionVectorControl TypeSystemFormatgRNA Type
CRISPR06CRISPR Universal Non-target Negative Control 1, Cas9+gRNA Plasmidp01Neg.
MammalianPlasmid
DNA
Cas9+gRNA
CRISPR07CRISPR Universal Non-target Negative Control 2, Cas9+gRNA Plasmidp01Neg.MammalianPlasmid
DNA
Cas9+gRNA
CRISPR08CRISPR Universal Non-target Negative Control 3, Cas9+gRNA Plasmidp01Neg.MammalianPlasmid
DNA
Cas9+gRNA
CRISPR17CRISPR Activator Human Oct4 Positive Control Plasmid, gRNA Only Expression Plasmidp03Pos.MammalianPlasmid
DNA
gRNA only
CRISPR12CRISPR-Lenti Universal Non-Target Negative Control 1, Cas9+gRNA Lenti Plasmid (vector)LV01Neg.LentiviralPlasmid
DNA
Cas9+gRNA
CRISPR18CRISPR-Lenti Universal Non-target Negative Control 1, gRNA Only Lenti Plasmid (Sanger vector)LV04Neg.LentiviralPlasmid
DNA
gRNA only
CRISPR19CRISPR-Lenti Universal Non-target Negative Control 2, gRNA Only Lenti Plasmid (Sanger vector)LV04Neg.LentiviralPlasmid
DNA
gRNA only
CRISPR20CRISPR-Lenti Universal Non-target Negative Control 3, gRNA Only Lenti Plasmid (Sanger vector)LV04Neg.LentiviralPlasmid
DNA
gRNA only
CRISPR12VCRISPR-Lenti Universal Non-Target Negative Control 1, Cas9+gRNA Lentiviral Particles (vector)LV01Neg.LentiviralLentivirusCas9+gRNA
CRISPR12HCRISPR-Lenti Universal Non-Target Negative Control 1, Cas9+gRNA Lentiviral Particles, High Titer (vector)LV01Neg.LentiviralLentivirusCas9+gRNA
CRISPR15HGecko2-Lenti Universal Non-Target Negative Control 1, gRNA Only High Titer Lentiviral Particles (Gecko2 vector)LV02Neg.LentiviralLentivirusgRNA only
CRISPR18VCRISPR-Lenti Universal Non-target Negative Control 1, gRNA Only Lentiviral Particles (Sanger vector)LV04Neg.LentiviralLentivirusgRNA only
CRISPR19VCRISPR-Lenti Universal Non-target Negative Control 2, gRNA Only Lentiviral Particles (Sanger vector)LV04Neg.LentiviralLentivirusgRNA only
CRISPR20VCRISPR-Lenti Universal Non-target Negative Control 3, gRNA Only Lentiviral Particles (Sanger vector)LV04Neg.LentiviralLentivirusgRNA only
CRISPR01CRISPR Human EMX1 Positive Control Plasmid, gRNA Only Expression Plasmid, includes Cas9 Expression Plasmid (vector)p03Pos.MammalianPlasmid
DNA
gRNA only
CRISPR02CRISPR Nickase Human EMX1 Positive
Control Plasmids (gRNA Only Expression
Plasmids, Includes Cas9-D10A Plasmid)
p03Pos.MammalianPlasmid
DNA
gRNA only
CRISPR11CRISPR-Lenti Human EMX1 Positive Control, Cas9+gRNA Lenti Plasmid (vector)LV01Pos.LentiviralPlasmid
DNA
Cas9+gRNA
CRISPR13CRISPR-Lenti Human HPRT1 Positive Control, Cas9+gRNA Lenti Plasmid (vector)LV01Pos.LentiviralPlasmid
DNA
Cas9+gRNA
CRISPR21CRISPR-Lenti Human HPRT1 Positive Control, gRNA Only Lenti Plasmid (Sanger vector)LV04Pos.LentiviralPlasmid
DNA
gRNA only
CRISPR11VCRISPR-Lenti Human EMX1 Positive Control, Cas9+gRNA Lentiviral Particles (vector)LV01Pos.LentiviralLentivirusCas9+gRNA
CRISPR13VCRISPR-Lenti Human HPRT1 Positive Control, Cas9+gRNA Lentiviral Particles (vector)LV01Pos.LentiviralLentivirusCas9+gRNA
CRISPR13HCRISPR-Lenti Human HPRT1 Positive Control, Cas9+gRNA Lentiviral Particles, High Titer (vector)LV01Pos.LentiviralLentivirusCas9+gRNA
CRISPR16HGecko2-Lenti Human HPRT1 Positive Control, gRNA Only High Titer Lentiviral Particles (Gecko2 vector)LV02Pos.LentiviralLentivirusgRNA only
CRISPR21VCRISPR-Lenti Human HPRT1 Positive Control, gRNA Only Lentiviral Particles (Sanger vector)LV04Pos.LentiviralLentivirusgRNA only
CRISPRPL01CRISPR GUS GAPDH Reporter Control for Monocotsp62Pos.PlantPlasmid
DNA
Cas9+gRNA
CRISPRPL02CRISPR GUS GAPDH Reporter Control for Dicotsp63Pos.PlantPlasmid
DNA
Cas9+gRNA

Positive Controls

Product No.DescriptionVectorControl TypeSystemFormatgRNA Type
CRISPR01CRISPR Human EMX1 Positive Control Plasmid, gRNA Only Expression Plasmid, includes Cas9 Expression Plasmid (vector)p03Pos.MammalianPlasmid
DNA
gRNA only
CRISPR02CRISPR Nickase Human EMX1 Positive
Control Plasmids (gRNA Only Expression
Plasmids, Includes Cas9-D10A Plasmid)
p03Pos.MammalianPlasmid
DNA
gRNA only
CRISPR11CRISPR-Lenti Human EMX1 Positive Control, Cas9+gRNA Lenti Plasmid (vector)LV01Pos.LentiviralPlasmid
DNA
Cas9+gRNA
CRISPR13CRISPR-Lenti Human HPRT1 Positive Control, Cas9+gRNA Lenti Plasmid (vector)LV01Pos.LentiviralPlasmid
DNA
Cas9+gRNA
CRISPR21CRISPR-Lenti Human HPRT1 Positive Control, gRNA Only Lenti Plasmid (Sanger vector)LV04Pos.LentiviralPlasmid
DNA
gRNA only
CRISPR11VCRISPR-Lenti Human EMX1 Positive Control, Cas9+gRNA Lentiviral Particles (vector)LV01Pos.LentiviralLentivirusCas9+gRNA
CRISPR13VCRISPR-Lenti Human HPRT1 Positive Control, Cas9+gRNA Lentiviral Particles (vector)LV01Pos.LentiviralLentivirusCas9+gRNA
CRISPR13HCRISPR-Lenti Human HPRT1 Positive Control, Cas9+gRNA Lentiviral Particles, High Titer (vector)LV01Pos.LentiviralLentivirusCas9+gRNA
CRISPR16HGecko2-Lenti Human HPRT1 Positive Control, gRNA Only High Titer Lentiviral Particles (Gecko2 vector)LV02Pos.LentiviralLentivirusgRNA only
CRISPR21VCRISPR-Lenti Human HPRT1 Positive Control, gRNA Only Lentiviral Particles (Sanger vector)LV04Pos.LentiviralLentivirusgRNA only
CRISPRPL01CRISPR GUS GAPDH Reporter Control for Monocotsp62Pos.PlantPlasmid
DNA
Cas9+gRNA
CRISPRPL02CRISPR GUS GAPDH Reporter Control for Dicotsp63Pos.PlantPlasmid
DNA
Cas9+gRNA

Plant CRISPR

Explore ready-to-use cas9 and guide RNA (gRNA) expression plasmids for monocots and dicots

  • Our plant CRISPR/Cas9 products are intended for Agrobacterium-mediated plant transformation or biolistic microparticle bombardment or protoplast transformation
  • A codon optimized Cas9 protein and a gRNA are expressed from a single vector and provided as ready-to-use, transfection-grade DNA.

Bacterial CRISPR

Our E. coli CRISPR/Cas-mediated Lambda-Red (λ-Red) homologous recombination (HR) vector system facilitates gene editing through the homology-directed repair (HDR) of double-stranded DNA breaks (DSBs) created by Cas9 endonuclease, using either ssDNA or dsDNA as an editing template.

Mammalian System Vectors

Vector No.DescriptionOrder
Clones
Cas9/gRNA
Content
Format
Availability
Other Features
FluorophoreCas9 type
p01U6-gRNA:CMV-Cas9-2A-tGFPp01 clonesCas9+gRNAPlasmid DNAGFPS. pyogenes
p02U6-gRNA:CMV-Cas9-2A-tRFPp02 clonesCas9+gRNAPlasmid DNARFPS. pyogenes
p04U6-gRNA:CMV-eCas9-2a-tGFPp04 clonesCas9+gRNAPlasmid DNAGFPenhanced specificity
p03U6-gRNAp03 clonesgRNA onlyPlasmid DNA  

Lentiviral Vectors

Vector
No.
DescriptionOrder
Clones
Cas9/gRNA ContentFormat
Availability
Selection
Method
LV01U6-gRNA:ef1a-puro-2A-Cas9-2A-tGFPLV01 clonesCas9+gRNAPlasmid DNA &
Lentivirus
Fluorophore (GFP) & Puromycin
LV05U6-gRNA:EF1a-Cas9+FLAG-2A-PuroLV05 clonesCas9+gRNAPlasmid & LentivirusPuromycin
LV06CRISPRa SAM U6-gRNA:EF1a-PuroLV06 clonesCRISPR activator gRNAPlasmid & LentivirusPuromycin
LV07CRISPRa SAM U6-gRNA:EF1a-ZeoLV07 clonesCRISPR activator gRNAPlasmid & LentivirusZeo
LV04U6-gRNA:hPGK-puro-2A-tBFPSanger QP KO clones
gRNA onlyPlasmid DNA &
Lentivirus
Fluorophore (BFP) & Puromycin
LV03U6-gRNA:ef1a-tGFPLV03 clonesgRNA onlyPlasmid DNA &
Lentivirus
Fluorophore (GFP)
LV02U6-gRNA:ef1a-puroLV02 clonesgRNA onlyPlasmid DNA &
Lentivirus
Puromycin

Plant Vectors

Vector
No.
DescriptionOrder
Clones
Cas9/gRNA
Content
Format
Availability
SpeciesPlasmid
Type
Selection
p63(dicot)U6-gRNA:CMV-Cas9-beta glucuronidase (Agrobacterium plasmid)p63 clonesCas9+
gRNA
Plasmid
DNA
DicotAgro-bacteriumBeta
Glucuron-
idase
p55(dicot)U6-gRNA:CMV-Cas9-bar (Agrobacterium plasmid)p55 clonesCas9+
gRNA
Plasmid
DNA
DicotAgro-bacteriumBiala-
phos
p53(dicot)U6-gRNA:CMV-Cas9-hyg (Agrobacterium plasmid)p53 clonesCas9+
gRNA
Plasmid
DNA
DicotAgro-bacteriumHygro-
mycin
p54(dicot)U6-gRNA:CMV-Cas9-neo (Agrobacterium plasmid)p54 clonesCas9+
gRNA
Plasmid
DNA
DicotAgro-bacteriumNeo-
mycin
p61(dicot)U6-gRNA:CMV-Cas9-bar (bioballistic plasmid)p61 clonesCas9+
gRNA
Plasmid
DNA
DicotBio-BallisticBiala-
phos
p59(dicot)U6-gRNA:CMV-Cas9-hyg (bioballistic plasmid)p59 clonesCas9+
gRNA
Plasmid
DNA
DicotBio-BallisticHygro-
mycin
p60(dicot)U6-gRNA:CMV-Cas9-neo (bioballistic plasmid)p60 clonesCas9+
gRNA
Plasmid
DNA
DicotBio-BallisticNeo-
mycin
p62(monocot)U6-gRNA:CMV-Cas9-beta glucuronidase (Agrobacterium plasmid)p62 clonesCas9+
gRNA
Plasmid
DNA
MonocotAgro-bacteriumBeta
Glucuron-
idase
p52(monocot)U6-gRNA:CMV-Cas9-bar (Agrobacterium plasmid)p52 clonesCas9+
gRNA
Plasmid
DNA
MonocotAgro-bacteriumBiala-
phos
p50(monocot) U6-gRNA:CMV-Cas9-hyg (Agrobacterium plasmid)p50 clonesCas9+
gRNA
Plasmid
DNA
MonocotAgro-bacteriumHygro-
mycin
p51(monocot)U6-gRNA:CMV-Cas9-neo (Agrobacterium plasmid)p51 clonesCas9+
gRNA
Plasmid
DNA
MonocotAgro-bacteriumNeo-
mycin
p58(monocot)U6-gRNA:CMV-Cas9-bar (bioballistic plasmid)p58 clonesCas9+
gRNA
Plasmid
DNA
MonocotBio-BallisticBiala-
phos
p56(monocot)U6-gRNA:CMV-Cas9-hyg (bioballistic plasmid)p56 clonesCas9+
gRNA
Plasmid
DNA
MonocotBio-BallisticHygro-
mycin
p57(monocot)U6-gRNA:CMV-Cas9-neo (bioballistic plasmid)p57 clonesCas9+
gRNA
Plasmid
DNA
MonocotBio-BallisticNeo-
mycin

Bacterial Vectors

Vector No.DescriptionOrder ClonesCas9/gRNA ContentFormat AvailabilitySelection
p10(bacteria) J23119-gRNA-amp
p10 clones
gRNA only
Plasmid DNAAmpicillin

Vector Maps and Sequences

Click on the images below for a larger view.

p01 Vector

Download Fully Annotated p01 Map
Download p01 FASTA Sequence

p02 Vector

Download Fully Annotated p02 Map
Download p02 FASTA Sequence

p03 Vector

Download Fully Annotated p03 Map
Download p03 FASTA Sequence

 

p04 Vector

Download Fully Annotated p04 Map
Download p04 FASTA Sequence

p05 Vector

Download Fully Annotated p05 Map
Download p05 FASTA Sequence

p10 Vector

Download Fully Annotated p10 Map
Download p10 FASTA Sequence

 

p50 Vector

Download Fully Annotated p50 Map
Download p50 FASTA Sequence

p51 Vector

Download Fully Annotated p51 Map
Download p51 FASTA Sequence

p52 Vector

Download Fully Annotated p52 Map
Download p52 FASTA Sequence

 

p53 Vector

Download Fully Annotated p53 Map
Download p53 FASTA Sequence

p54 Vector

Download Fully Annotated p54 Map
Download p54 FASTA Sequence

p55 Vector

Download Fully Annotated p55 Map
Download p5 FASTA Sequence

 

p56 Vector

Download Fully Annotated p56 Map
Download p56 FASTA Sequence

p57 Vector

Download Fully Annotated p57 Map
Download p57 FASTA Sequence

p58 Vector

Download Fully Annotated p58 Map
Download p58 FASTA Sequence

 

p59 Vector

Download Fully Annotated p59 Map
Download p59 FASTA Sequence

p60 Vector

Download Fully Annotated p60 Map
Download p60 FASTA Sequence

p61 Vector

Download Fully Annotated p61 Map
Download p61 FASTA Sequence

 

p62 Vector

Download Fully Annotated p62 Map
Download p62 FASTA Sequence

p63 Vector

Download Fully Annotated p63 Map
Download p01 FASTA Sequence

LV01 Vector

Download Fully Annotated LV01 Map
Download LV01 FASTA Sequence

 

LV02 Vector

Download Fully Annotated LV02 Map
Download LV02 FASTA Sequence

LV03 Vector

Download Fully Annotated LV03 Map
Download LV03 FASTA Sequence

LV04 Vector

Download Fully Annotated LV04 Map
Download LV04 FASTA Sequence

 

LV05 Vector

Download Fully Annotated LV05 Map
Download LV05 FASTA Sequence

LV06 Vector

Download Fully Annotated LV06 Map
Download LV06 FASTA Sequence

LV07 Vector

Download Fully Annotated LV07 Map
Download LV07 FASTA Sequence

 

LV17 Vector

KRAB-dCas9 Vector

If you need any further information, please contact us here and a customer service representative will get back to you.

Product Guarantee

We are so confident in the performance of our synthetic gRNA products, that we fully guarantee the quality and performance of any gRNA we produce, including custom sequences. If your crRNA or sgRNA do not yield detectable cleavage at the intended target site, we will provide you a one-time replacement, free of charge.

To qualify for this guarantee, please send an image or sequencing data from a single experiment demonstrating detectable cleavage using one of our positive controls, side-by-side with the negative results from your synthetic gRNA. To receive your replacement, simply email oligotechserv@milliporesigma.com and include sample data from a representative experiment (T7E1, TIDE, or NGS).

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