- Design and Synthesis of Imidazopyrimidine Derivatives as Potent iNOS Dimerization Inhibitors.
Design and Synthesis of Imidazopyrimidine Derivatives as Potent iNOS Dimerization Inhibitors.
The open medicinal chemistry journal (2009-12-08)
Guo-Hua Chu, Bertrand Le Bourdonnec, Minghua Gu, Christopher W Ajello, Lara K Leister, Ian Sellitto, Joel A Cassel, Paul A Tuthill, Heather O' Hare, Robert N Dehaven, Roland E Dolle
PMID19966921
RESUMEN
A series of imidazopyrimidine derivatives with the general formula I was synthesized and identified as potent inhibitors of iNOS dimer formation, a prerequisite for proper functioning of the enzyme. Stille and Negishi coupling reactions were used as key steps to form the carbon-carbon bond connecting the imidazopyrimidine core to the central cycloalkenyl, cycloalkyl and phenyl ring templates.
MATERIALES
Referencia del producto
Marca
Descripción del producto