Saltar al contenido
Merck

Synthesis of C14,15-dihydro-C22,25-epi north unit of cephalostatin 1 via "red-ox" modifications of hecogenin acetate.

Organic letters (2008-12-06)
Seongmin Lee, Daniel Jamieson, Philip L Fuchs
RESUMEN

The C14,15-dihydro-C22,25-epi north unit of cephalostatin 1 has been synthesized in 11 operations from commercially available hecogenin acetate via multiple reductions and oxidations. The key transformations include (i) Cr(VI)-catalyzed E-ring opening, (ii) C17 hydroxylation, and (iii) a base-triggered cyclization cascade.

MATERIALES
Referencia del producto
Marca
Descripción del producto

Sigma-Aldrich
Chromium(VI) oxide, ACS reagent, ≥98.0%
Sigma-Aldrich
Chromium(VI) oxide, ReagentPlus®, 99.9% trace metals basis
Sigma-Aldrich
Chromium(VI) oxide, 99.99% trace metals basis