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HybridSPE®-PLus 96-Well solid phase extraction (SPE) Plate

Volume 2 mL, bed wt., 50 mg, pk of 1 ea

Sinónimos:

HybridSPE®-PLus

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About This Item

UNSPSC Code:
41104018
NACRES:
NB.21

product name

HybridSPE®-PLus 96-Well Plate, volume 2 mL, pk of 1 ea

description

96-well Plate

Quality Level

100

product line

HybridSPE®

composition

bed wt., 50 mg

packaging

pk of 1 ea

technique(s)

solid phase extraction (SPE): suitable

volume

2 mL

matrix active group

zirconia-based phase

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Categorías relacionadas

General description

HybridSPE-PLus is the next generation of HybridSPE-Phospholipid technology. The first of its kind, HybridSPE-Phospholipid technology was first introduced in 2008. It fuses the simple, standardized methodology of traditional protein precipitation with the specificity of solid phase extraction (SPE) for the simultaneous removal of proteins and phospholipids from biological samples prior to LC-MS analysis. Unlike other phospholipid removal products that use a hydrophobic retention mechanism to remove phsopholipids from biological samples, HybridSPE-Phospholipid technology uses a unique Lewis acid/base retention mechanism that allows it to separate phospholipids from even very hydrophobic analytes, such as vitamins, which are often retained along with phospholipids on competitive products.

Our HybridSPE-PLus products offer the same time-proven chemistry of our traditional HybridSPE-Phospholipid products coupled with manufacturing enhancements that stem from years of production experience. These manufacturing enhancements have allowed us to increase flow consistency and reduce sample hold up volumes, further improving analyte recoveries and assay reproducibility. We invite customers to take advantage of the newest technology; HybridSPE-PLus.

Features and Benefits

  • Simple 2-3 step standard methodology analogous to traditional protein precipitation provides simultaneous removal of both proteins and phospholipids
  • Unique Lewis acid/base retention mechanism effectively removes phospholipids from both hydrophilic and hydrophobic analytes of interest (unlike competitive chemistries) eliminating phospholipid-induced ion suppression
  • Highly reproducible, consistent product performance
  • Provides cleaner samples for longer column life and less instrument downtime
  • Available in 96-well and 1 mL cartridge dimensions

Legal Information

HybridSPE is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificados de análisis (COA)

Lot/Batch Number
18346801
18346804
18346803
18346802
18106101

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Artículos

Two Distinct Sample Prep Approaches to Overcome Matrix Effect in LC/MS of Serum or Plasma Samples

This article highlights the impact that sample matrix effects can have on LC/MS response and discusses two novel approaches to reduce it.

Method Optimization for LC-MS Analysis of Vitamin D Metabolite Critical Pairs in Serum

Using HybridSPE-Phospholipid, Ascentis Express, and Other LC-MS Workflow Components

Protocolos

Rapid, Sensitive, and Quantitative LC/MS/MS Determination of Digitoxin and Digoxin in Plasma

Immunoassay-based methods for digitoxin or digoxin exist, but are time consuming, labor intensive, and not selective due to similarities in their chemical structures.

LC/MS/MS Analysis of Interacting Cardiac Drugs Digoxin, Quinidine, Amiodarone and Verapamil on Titan™ C18

LC/MS/MS Analysis of Interacting Cardiac Drugs Digoxin, Quinidine, Amiodarone and Verapamil on Titan™ C18

Contenido relacionado

HPLC de moléculas pequeñas

Las moléculas pequeñas son iones y compuestos de peso molecular normalmente inferior a 900 dalton. Estos compuestos pueden separarse y analizarse con eficacia mediante HPLC, UHPLC y LC-MS utilizando principalmente partículas de sílice o fases estacionarias monolíticas con una amplia gama de composiciones químicas de la columna (modificaciones).

Small Molecule HPLC

Small molecules are ions and compounds of molecular weight typically less than 900 daltons. These compounds can be effectively separated and analyzed by HPLC, UHPLC and LC-MS using mainly silica particles or monolithic stationary phases with a broad range of column chemistries (modifications).

Solid Phase Extraction (SPE)

Solid phase extraction purifies samples for chromatographic analysis, improving data quality and protecting analytical columns.

Extracción en fase sólida (SPE)

La extracción en fase sólida (SPE) es una técnica utilizada para la preparación y la purificación rápidas y selectivas de la muestra antes del análisis cromatográfico (p. ej. HPLC, GC, TLC). La SPE se utiliza para cambiar matrices de muestra, concentrar analitos y eliminar interferencias y contaminantes con el fin de mejorar los datos y proteger la columna analítica.

Chromatograms

application for HPLC, application for SPE

Nuestro equipo de científicos tiene experiencia en todas las áreas de investigación: Ciencias de la vida, Ciencia de los materiales, Síntesis química, Cromatografía, Analítica y muchas otras.

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