Q1125

Quinine hydrochloride dihydrate

99-101% (titration), potassium channel blocker

• Fórmula empírica (notación de Hill): C₂₀H₂₄N₂O₂ · HCl · 2H₂O
• Número de CAS: 6119-47-7
• Peso molecular: 396.91
• Número CE: 205-001-1
• Número MDL: MFCD00078498
• Código UNSPSC: 12352210
• ID de la sustancia en PubChem: 57654577
• NACRES: NA.77

Propiedades

• Nombre del producto: Quinine hydrochloride dihydrate,
• Nivel de calidad: 200
• solubilidad: H₂O: 0.25/5 g/mL, clear, colorless
• espectro de actividad antibiótica: parasites
• Modo de acción: enzyme | inhibits
• cadena SMILES: O.Cl.[H][C@]1(C[C@@H]2CC[N@H]1C[C@@H]2C=C)[C@H](O)c3ccnc4ccc(OC)cc34
• InChI: 1S/C20H24N2O2.ClH.H2O/c1-3-13-12-22-9-7-14(13)10-19(22)20(23)16-6-8-21-18-5-4-15(24-2)11-17(16)18;;/h3-6,8,11,13-14,19-20,23H,1,7,9-10,12H2,2H3;1H;1H2/t13-,14-,19-,20+;;/m0../s1
• Clave InChI: SGVZDMWHXVXUBY-HZQSTTLBSA-N

Descripción

Descripción general

Quinine is derived from the stem of cinchona (quina-quina) tree. It is an alkaloid having various applications in the field of medicine. Quinine is a basic compound with aryl amino alcohol group.

Aplicación

Quinine hydrochloride dihydrate has been used in Drosophila larval behavioral assay. It has also been used in taste preference analysis among rats.

Acciones bioquímicas o fisiológicas

Potassium channel blocker

Quinine is widely used in the treatment of malaria. It possesses erythrocytic and gametocytocidal action against Plasmodium sp. It also serves as an analgesic drug. Upon administration, quinine is present mostly bound to α-1 acid glycoprotein in the body fluids. Quinine has the ability to cross the placenta and the blood brain barrier. It has a half-life of 11-18 hours. Tinnitus, hearing defects, nausea and headache are some of its side effects.

Información de seguridad

• Pictogramas: GHS08,GHS07
• Palabra de señalización: Danger
• Frases de peligro: H302,H317,H334
• Consejos de prudencia: P261 - P264 - P272 - P280 - P301 + P312 - P302 + P352
• Clasificaciones de peligro: Acute Tox. 4 Oral - Resp. Sens. 1 - Skin Sens. 1
• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 1
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable
• Equipo de protección personal: dust mask type N95 (US), Eyeshields, Faceshields, Gloves