The stability of Product 27655, Colistin Sodium Methanesulfonate, if stored at ambient temperature is not determined.
27655
Colistin sodium methanesulfonate
from Bacillus colistinus
Sinónimos:
Colimycin sodium methanesulfonate, Methanesulfonic acid derivative of Polymyxin E, Polymyxin E sodium methanesulfonate
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| Tamaño de envase | SKU | Disponibilidad | Precio |
|---|---|---|---|
| 1 g | Comprobar disponibilidad del carrito | $198.000 | |
| 5 g | Comprobar disponibilidad del carrito | $837.000 |
Acerca de este artículo
Fórmula empírica (notación de Hill):
C58H115N16Na5O28S5
Número CAS:
Peso molecular:
1759.90
NACRES:
NA.85
PubChem Substance ID:
UNSPSC Code:
51102829
EC Number:
232-516-9
MDL number:
Servicio técnico
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Permítanos ayudarlebiological source
Bacillus colistinus
Quality Level
form
powder or crystals
ign. residue
~20%
loss
≤5.0% loss on drying
color
white to off-white
pH
6.5-8.5
antibiotic activity spectrum
Gram-negative bacteria
mode of action
cell membrane | interferes
storage temp.
2-8°C
SMILES string
[Na+].[Na+].[Na+].[Na+].[Na+].CS([O-])(=O)=O.CS([O-])(=O)=O.CS([O-])(=O)=O.CS([O-])(=O)=O.CS([O-])(=O)=O.CCC(C)CCCCC(=O)N[C@@H](CCN)C(=O)N[C@@H](C(C)O)C(=O)N[C@@H](CCN)C(=O)N[C@H]1CCNC(=O)[C@@H](NC(=O)[C@H](CCN)NC(=O)[C@@H](CCN)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](CCN)NC1=O)C(C)O
InChI
1S/C53H100N16O13.5CH4O3S.5Na/c1-9-30(6)12-10-11-13-41(72)60-33(14-20-54)48(77)69-43(32(8)71)53(82)65-36(17-23-57)45(74)64-38-19-25-59-52(81)42(31(7)70)68-49(78)37(18-24-58)62-44(73)34(15-21-55)63-50(79)39(26-28(2)3)67-51(80)40(27-29(4)5)66-46(75)35(16-22-56)61-47(38)76;5*1-5(2,3)4;;;;;/h28-40,42-43,70-71H,9-27,54-58H2,1-8H3,(H,59,81)(H,60,72)(H,61,76)(H,62,73)(H,63,79)(H,64,74)(H,65,82)(H,66,75)(H,67,80)(H,68,78)(H,69,77);5*1H3,(H,2,3,4);;;;;/q;;;;;;5*+1/p-5/t30?,31-,32-,33+,34-,35+,36+,37+,38+,39+,40-,42+,43+;;;;;;;;;;/m1........../s1
InChI key
WSDSONZFNWDYGZ-BKFDUBCBSA-I
General description
Chemical structure: peptide
Application
Colistin sodium methanesulfate is used to permeabilize bacterial cell membranes and to study mannose-resistant haemagglutination.
Biochem/physiol Actions
Mode of Action: Binds to lipids on the cell cytoplasmic membrane of Gram-negative bacteria and disrupts the cell wall integrity.
Antimicrobial spectrum: Gram-negative bacteria.
Antimicrobial spectrum: Gram-negative bacteria.
Colistin sodium methanesulfate is a cyclopolypeptide antibiotic with endotoxin-binding capacity Colistin′s activity stems from the hydrophobic and hydrophillic regions. They solubilze the cytoplasmic membrane which contributes to the bactericidal effect [1].
Packaging
1g, 5g
Other Notes
Keep container tightly closed in a dry and well-ventilated place. Keep in a dry place. Keep in a dry place.
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Este artículo | |||
|---|---|---|---|
| antibiotic activity spectrum Gram-negative bacteria | antibiotic activity spectrum Gram-negative bacteria | antibiotic activity spectrum - | antibiotic activity spectrum - |
| mode of action cell membrane | interferes | mode of action cell membrane | interferes | mode of action - | mode of action - |
| Quality Level 200 | Quality Level 200 | Quality Level 300 | Quality Level - |
| form powder or crystals | form powder | form - | form solid |
| biological source Bacillus colistinus | biological source - | biological source - | biological source - |
| storage temp. 2-8°C | storage temp. 2-8°C | storage temp. -10 to -25°C | storage temp. −20°C |
Clase de almacenamiento
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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Matthew E Falagas et al.
Expert review of anti-infective therapy, 6(5), 593-600 (2008-10-14)
Despite the constantly increasing need for new antimicrobial agents, antibiotic drug discovery and development seem to have greatly decelerated in recent years. Presented with the significant problem of advancing antimicrobial resistance, the global scientific community has attempted to find alternative
Roberto Imberti et al.
Chest, 138(6), 1333-1339 (2010-06-19)
Infections caused by multidrug-resistant gram-negative bacteria have caused a resurgence of interest in colistin. To date, information about pharmacokinetics of colistin is very limited in critically ill patients, and no attempts have been made to evaluate its concentration in BAL.
M.J. Rogers et al.
Infection (Munich), 14, 79-79 (1986)
Número de artículo de comercio global
| SKU | GTIN |
|---|---|
| 27655-1G | 04061826185544 |
| 27655-5G | 04061835541171 |
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For how long can product 27655 (Colistin Sodium Methanesulfonate) be stored at RT in powder form before loosing any efficacy? Can you provide any RT storage stability/efficacy data?
1 answer-
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