Saltar al contenido
Merck
Todas las fotos(1)

Key Documents

06-225

Sigma-Aldrich

Anti-c-Jun Antibody

serum, Upstate®

Sinónimos:

Activator protein 1, AP1, p39, Proto-oncogene c-Jun, Transcription factor AP-1, V-jun avian sarcoma virus 17 oncogene homolog

Iniciar sesiónpara Ver la Fijación de precios por contrato y de la organización


About This Item

UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41

biological source

rabbit

Quality Level

antibody form

serum

antibody product type

primary antibodies

clone

polyclonal

species reactivity

human, avian, mouse

manufacturer/tradename

Upstate®

technique(s)

immunocytochemistry: suitable
immunoprecipitation (IP): suitable
western blot: suitable

isotype

IgG

NCBI accession no.

UniProt accession no.

shipped in

dry ice

target post-translational modification

unmodified

Gene Information

human ... JUN(3725)
mouse ... Jun(16476)

General description

c-Jun is a component of the transcription factor AP-1 that binds and activates transcription at TRE/AP-1 elements and appears to be a major downstream target of the SAPK/JNK signaling pathway. The transcriptional activity of c-Jun is regulated by phosphorylation at Ser63 and Ser73. Extracellular signals including growth factors, transforming oncoproteins and UV irradiation stimulate phosphorylation of c-Jun at Ser63/73 and activate c-Jun dependent transcription. Mutation of Ser63/73 renders c-Jun nonresponsive to mitogenic and stress induced
signaling pathways. The MAP kinase homologue, SAPK/JNK, binds to the N-terminal region of c-Jun and phosphorylates c-Jun at Ser63/73. In addition, the activity of SAPK/JNK is stimulated by the same signals that activate c-Jun.

Specificity

c-Jun

Immunogen

Trp E fusion-protein containing the DNA binding domain of avian c-Jun

Application

Detect c-Jun, also known as transcription factor AP-1, with Anti-c-Jun rabbit polyclonal antiserum, Cat. No. 06-225, that has been demonstrated to work in Immunocytochemistry, Immunoprecipitation, and Western blotting.
Research Category
Epigenetics & Nuclear Function
Research Sub Category
Transcription Factors

Quality

routinely evaluated by immunoblot on RIPA lysates from human A431 cells or in Jurkat cell lysate

Target description

35-39 kDa

Linkage

Replaces: 04-210

Physical form

Antiserum
Whole rabbit antiserum containing 0.05% sodium azide

Storage and Stability

2 years at -20°C

Analysis Note

Control
Positive Antigen Control: Catalog #12-303, Jurkat cell lysate.

Legal Information

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

¿No encuentra el producto adecuado?  

Pruebe nuestro Herramienta de selección de productos.

Optional

Referencia del producto
Descripción
Precios

Storage Class

10 - Combustible liquids

wgk_germany

WGK 1


Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

¿Ya tiene este producto?

Encuentre la documentación para los productos que ha comprado recientemente en la Biblioteca de documentos.

Visite la Librería de documentos

Myristylation alters DNA-binding activity and transactivation of FBR (gag-fos) protein
Kamata, N., et al
Molecular and cellular biology, 11, 765-772 (1991)
The oncogenic microRNA OncomiR-21 overexpressed during Marek's disease lymphomagenesis is transactivated by the viral oncoprotein Meq.
Stik, G; Dambrine, G; Pfeffer, S; Rasschaert, D
Journal of virology null
Characterization of the chromosomal binding sites and dimerization partners of the viral oncoprotein Meq in Marek's disease virus-transformed T cells.
Alon M Levy, Yoshihiro Izumiya, Peter Brunovskis, Liang Xia, Mark S Parcells et al.
Journal of virology null
Multiple mitogen-activated protein kinases are regulated by hyperosmolality in mouse IMCD cells.
T Berl, G Siriwardana, L Ao, L M Butterfield, L E Heasley, T Berl, G Siriwardana, L Ao et al.
The American Journal of Physiology null
Varicella-zoster virus infection of human fibroblast cells activates the c-Jun N-terminal kinase pathway.
Zapata, HJ; Nakatsugawa, M; Moffat, JF
Journal of virology null

Nuestro equipo de científicos tiene experiencia en todas las áreas de investigación: Ciencias de la vida, Ciencia de los materiales, Síntesis química, Cromatografía, Analítica y muchas otras.

Póngase en contacto con el Servicio técnico