Saltar al contenido
Merck
Todas las fotos(1)

Documentos

860842P

Avanti

18:0(2R-OH) Sulfo GalCer

Avanti Research™ - A Croda Brand 860842P, powder

Sinónimos:

3-O-sulfo-D-galactosyl-β1-1′-N-[2"(R)-hydroxystearyl]-D-erythro-sphingosine (ammonium salt), (synthetic)

Iniciar sesiónpara Ver la Fijación de precios por contrato y de la organización
Todas las fotos(1)

About This Item

Fórmula empírica (notación de Hill):
C42H84N2O12S
Número de CAS:
2260670-26-4
Peso molecular:
841.19
UNSPSC Code:
12352211
NACRES:
NA.25

form

powder

packaging

pkg of 1 × 1 mg (860842P-1mg)

manufacturer/tradename

Avanti Research™ - A Croda Brand 860842P

lipid type

sphingolipids

shipped in

dry ice

storage temp.

−20°C

SMILES string

[H][C@](/C=C/CCCCCCCCCCCCC)(O)[C@@]([H])(NC([C@H](O)CCCCCCCCCCCCCCCC)=O)CO[C@H](O1)[C@H](O)[C@@H](OS([O-])(=O)=O)[C@H]([C@H]1CO)O.[NH4+]

General description

18:0(2R-OH) Sulfo GalCer, also known as 3-O-sulfo-D-galactosyl-β1-1′-N-[2"(R)-hydroxystearyl]-D-erythro-sphingosine, is a sulfatide that belongs to the class of sphingolipids. It is highly found in membranous myelin sheath formed around nerve axons in gangliosides. This sulfated galactosylceramide contains 3-O-sulfo-β-d-galactose moiety linked to transmembrane-embedded unique ceramide containing 18C long chain base fatty acid (stearic acid) with 2′-hydroxyl group in R configuration.

Biochem/physiol Actions

Sulfatides are involved in various cellular processes such as protein trafficking, signal transduction and neuronal cell differentiation. Accumulation of sulfoglycolipids (mainly sulfo-galactosylceramide, S-GalCer) in lysosomes, due to the inherited deficiency of arylsulfatase A (ASA), causes metachromatic leukodystrophy in humans. In mice, deficiency of sulfatide causes paralysis due to demyelination.

Packaging

5 mL Amber Glass Screw Cap Vial (860842P-1mg)

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Storage Class

11 - Combustible Solids

flash_point_f

No data available

flash_point_c

No data available

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

¿Ya tiene este producto?

Encuentre la documentación para los productos que ha comprado recientemente en la Biblioteca de documentos.

Visite la Librería de documentos

Vongsavanh Phongsisay et al.
Molecular immunology, 63(2), 595-599 (2014-08-31)
Axonal Guillain-Barré syndrome (GBS) is an autoimmune neuropathy characterized by limb weakness and/or paralysis due to the presence of autoantibodies against brain glycolipids. The immune receptors that recognize these autoimmune targets have not been described. In this study, 12 C-type
Analysis of complex lipidomes
Medical Applications of Mass Spectrometry, 116(2), 223-249 (2008)
Analysis of complex lipidomes
Medical Applications of Mass Spectrometry, 116(2), 223-249 (2008)
R Lüllmann-Rauch et al.
Histochemistry and cell biology, 116(2), 161-169 (2001-10-31)
The inherited deficiency of arylsulfatase A (ASA) causes lysosomal accumulation of sulfoglycolipids (mainly sulfo-galactosylceramide, S-GalCer ) and leads to metachromatic leukodystrophy in humans. Among visceral organs, kidneys are particularly affected. In the present study, the regional distribution and temporal development

Nuestro equipo de científicos tiene experiencia en todas las áreas de investigación: Ciencias de la vida, Ciencia de los materiales, Síntesis química, Cromatografía, Analítica y muchas otras.

Póngase en contacto con el Servicio técnico