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840030P

Avanti

06:0 PS

1,2-dihexanoyl-sn-glycero-3-phospho-L-serine (sodium salt), powder

Sinónimos:

PS(6:0/6:0)

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About This Item

Fórmula empírica (notación de Hill):
C18H33NO10PNa
Número de CAS:
321862-85-5
Peso molecular:
477.42
UNSPSC Code:
51191904
NACRES:
NA.25

assay

>99% (TLC)

form

powder

packaging

pkg of 1 × 10 mg (840030P-10mg)
pkg of 1 × 25 mg (840030P-25mg)

manufacturer/tradename

Avanti Research™ - A Croda Brand 840030P

lipid type

phospholipids
cardiolipins

shipped in

dry ice

storage temp.

−20°C

SMILES string

[H][C@@](COP([O-])(OC[C@](C([O-])=O)([H])[NH3+])=O)(OC(CCCCC)=O)COC(CCCCC)=O.[Na+]

InChI

1S/C18H34NO10P.Na/c1-3-5-7-9-16(20)26-11-14(29-17(21)10-8-6-4-2)12-27-30(24,25)28-13-15(19)18(22)23;/h14-15H,3-13,19H2,1-2H3,(H,22,23)(H,24,25);/q;+1/p-1/t14-,15+;/m1./s1

InChI key

OPDYVXCKOQKYDZ-LIOBNPLQSA-M

Categorías relacionadas

General description

Phosphatidylserine (PS) is an acidic phospholipid. Approximately 15–33 mol% of PS is present in the inner leaflet of the plasma membrane.

Application

06:0 PS may be used to study its effect on α-syn (α-synuclein) oligomerization by DA (dopamine) and as a phospholipid substrate to determine the kinetic parameters for phospholipase C by chromogenic assay. It has also been used in the preparation of phospholipid vesicles.

Biochem/physiol Actions

Phosphatidylserine (PS) participates in several signaling pathways. This membrane phospholipid controls the Akt (protein kinase B) phosphorylation process.

Packaging

5 mL Clear Glass Sealed Ampule (840030P-10mg)
5 mL Clear Glass Sealed Ampule (840030P-25mg)

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Storage Class

11 - Combustible Solids

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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Akt-GSK3 beta Pro-survival Signaling Pathway in Cerebral Ischemic Injury
Primer on Kidney Diseases, Volume 953, 269-272 (2017)
Analysis of complex lipidomes
Medical Applications of Mass Spectrometry, 223-249 (2008)
Analysis of complex lipidomes
Medical Applications of Mass Spectrometry, 223-249 (2008)
Mingquan Guo et al.
Journal of molecular neuroscience : MN, 33(1), 67-73 (2007-09-29)
Phosphatidylserine (PS), the major acidic phospholipid class in eukaryotic biomembranes, plays an important role in various signaling pathways. We have previously demonstrated that docosahexaenoic acid (DHA, 22:6n-3) positively modulates PS biosynthesis and accumulation in neuronal cells, promoting survival. In this
Chi L L Pham et al.
Bioscience reports, 33(5) (2013-09-27)
The deposition of α-syn (α-synuclein) as amyloid fibrils and the selective loss of DA (dopamine) containing neurons in the substantia nigra are two key features of PD (Parkinson's disease). α-syn is a natively unfolded protein and adopts an α-helical conformation
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Critical Micelle Concentrations (CMCs) - Avanti® Polar Lipids

The critical micelle concentration (CMC) can be approximately defined as the lipid monomer concentration at which appreciable amounts (>5% of total) of micellar aggregates first begin to appear in the equilibrium: nM1<=>Mn

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