- Metabolic flux analysis and the NAD(P)H/NAD(P)
Metabolic flux analysis and the NAD(P)H/NAD(P)
Microbial cell factories (2018-01-24)
Andres García, Pau Ferrer, Joan Albiol, Tania Castillo, Daniel Segura, Carlos Peña
PMID29357933
ABSTRACT
Azotobacter vinelandii is a bacterium that produces alginate and polyhydroxybutyrate (P3HB); however, the role of NAD(P)H/NAD(P) The results reveal that changes in the oxygen availability have an important effect on the metabolic fluxes and intracellular NADPH/NADP We have demonstrated that changes in oxygen availability affect the internal redox state of the cell and carbon metabolic fluxes. This also has a strong impact on the TCA cycle and PP pathway as well as on alginate and P3HB biosynthetic fluxes.
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