- Simple and efficient synthesis of 2-[(18)F]fluoroethyl triflate for high yield (18)fluoroethylation.
Simple and efficient synthesis of 2-[(18)F]fluoroethyl triflate for high yield (18)fluoroethylation.
Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine (2014-09-06)
Tanja Peters, Andreas Vogg, Iris M Oppel, Jörn Schmaljohann
PMID25189703
ABSTRACT
The [(18)F]fluoroethyl moiety has been widely utilized in the synthesis of (18)F-labelled compounds. The aim of this work was the reliable synthesis of [(18)F]FEtOTf with a novel strategy to increase the reactivity of the commonly used [(18)F]FEB and [(18)F]FEtOTos. [(18)F]FEtOTf and the intermediate [(18)F]FEtOH were synthesized in high RCY (78% and 85%, respectively) and purified by SPE. The high potency of [(18)F]FEtOTf was shown by the efficient alkylation of the deactivated nucleophile aniline under mild conditions, as well as by the synthesis of [(18)F]FEC.
MATERIALS
Product Number
Brand
Product Description
SKU
Pack Size
Availability
Price
Quantity
SKU
Pack Size
Availability
Price
Quantity
SKU
Pack Size
Availability
Price
Quantity
SKU
Pack Size
Availability
Price
Quantity
SKU
Pack Size
Availability
Price
Quantity
SKU
Pack Size
Availability
Price
Quantity
SKU
Pack Size
Availability
Price
Quantity