This product has not been validated for cell-based experiments. However, literature indicates that it has been used successfully in cell-based experiments. For more information, please see references provided on the product web page. https://www.sigmaaldrich.com/en/product/sigma/e3520
E3520
Ebselen
powder, ≥98% (TLC)
Synonym(s):
2-Phenyl-1,2-benzisoselenazol-3(2H)-one
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| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| 25 mg | Check Cart for Availability | CLP 198,000 | |
| 100 mg | Check Cart for Availability | CLP 609,000 |
About This Item
Empirical Formula (Hill Notation):
C13H9NOSe
CAS Number:
Molecular Weight:
274.18
UNSPSC Code:
12352202
PubChem Substance ID:
NACRES:
NA.77
MDL number:
Product Name
Ebselen, cysteine modifier
Quality Segment
assay
≥98% (TLC)
form
powder
mp
176-182 °C
solubility
chloroform: 19.60-20.40 mg/mL, clear, yellow
storage temp.
2-8°C
SMILES string
O=C1N([Se]c2ccccc12)c3ccccc3
InChI
1S/C13H9NOSe/c15-13-11-8-4-5-9-12(11)16-14(13)10-6-2-1-3-7-10/h1-9H
InChI key
DYEFUKCXAQOFHX-UHFFFAOYSA-N
General description
Ebselen is a sympathomimetic amine.
Application
Ebselen has been used as a:
extensor digitorum longus (fast-twitch) muscle
- voltage-dependent calcium channels (VDCCs) blocker[1]
- glutathione peroxidase mimetic to test its inhibitory effect on contraction-mediated deoxy glucose (2-DG) uptake in mouse
extensor digitorum longus (fast-twitch) muscle
- glucocerebrosidase inhibitor
- hepatitis C virus helicase inhibitor[2]
Biochem/physiol Actions
Ebselen, a glutathione-peroxidase-mimic, elicits anti-inflammatory activity. It also has anti-atherosclerotic functionality. Ebselen displays antibacterial action on) multidrug-resistant Staphylococcus aureus (MRSA) infections and could be a potential therapeutic target for treating MRSA based skin infection. It is regarded as neuroprotective agent and elicits chemopreventive functionality in inflammation-associated carcinogenesis.
An organo-selenium compound possessing antioxidant properties. Inhibits mammalian lipoxygenases in the absence of thiol groups, and glutathione S-transferase and papain via the interaction with cysteine residues. Also inhibits indoleamine 2,3-dioxygenase by covalently modifying a cysteine residue, the effect being reversible with dithiothreitol.[3] Inhibits oxidation of low density lipoproteins (LDL).
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This Item | |||
|---|---|---|---|
| assay ≥98% (TLC) | assay ≥98% (HPLC) | assay ≥98% (HPLC) | assay ≥98% (HPLC) |
| Quality Level 200 | Quality Level 100 | Quality Level 100 | Quality Level 100 |
| form powder | form powder | form powder | form powder |
| solubility chloroform: 19.60-20.40 mg/mL, clear, yellow | solubility DMSO: 5 mg/mL (clear solution) | solubility DMSO: 2 mg/mL, clear | solubility DMSO: 20 mg/mL, clear |
| storage temp. 2-8°C | storage temp. 2-8°C | storage temp. 2-8°C | storage temp. 2-8°C |
| mp 176-182 °C | mp - | mp - | mp - |
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signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - STOT RE 2
Storage Class
6.1D - Non-combustible acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects
wgk
WGK 3
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Articles
Antioxidants protect biological systems from oxidative damage produced by oxygen-containing free radicals and from redoxactive transition metal ions such as iron, copper, and cadmium.
Uncover properties and applications of the cysteine protease papain and find inhibitors, substrates, and other papain products.
Global Trade Item Number
| SKU | GTIN |
|---|---|
| E3520-100MG | 04061833603314 |
| E3520-25MG | 04061833603321 |
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Hello, we recently ordered this product (Ebselen, Cat# E3520). I dissolved it in DMSO (5 mg/mL) and plan to use it in cell experiments. However, I just noticed that the purity is ≥98% (TLC). Would this be suitable for cell-based experiments.Thank you.
1 answer-
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