Skip to Content
Merck
All Photos(3)

Key Documents

View All Documentation

CHOK1

SAFC

CHOZN® CHO K1 Host Cell Line

Suspension-adapted in CD media

Sign Into View Organizational & Contract Pricing
All Photos(3)

About This Item

UNSPSC Code:
12352200

description

CHOK1 cell line derived from ECACC CHO K1

Quality Level

200

shipped in

dry ice

storage temp.

−196°C

Related Categories

General description

A subclone of the parental CHO cell line, which was derived from the ovary of an adult Chinese hamster. Cells require proline due to the absence of the gene for proline synthesis, the block in the biosynthetic chain lies in the step converting glutamic acid to glutamine γ serialdehyde. They undergo morphological changes in response to cholera toxin.
CHO-K1 cells derived from ECACC CHO K1 and adapted to suspension and serum-free, chemically defined media. Cells are cGMP banked in chemically defined, animal component-free EX-CELL® CD CHO Fusion medium.

Cell Line Origin

Hamster Chinese ovary. The parental CHO-K1 cell line was originated by Puck in 1957.

Physical form

CHOZN CHO K1 cells are provided to customers in vials containing 1 mL at 107 cells/mL. Cells are banked in EX-CELL CD Fusion medium containing 4mM L glutamine and 7% DMSO.

Legal Information

The CHOZN CHO K1 cell line is sold for research use only. For use of this cell line in a commercial process, a commercial license must be taken.
CHOZN is a registered trademark of Merck KGaA, Darmstadt, Germany
EX-CELL is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class Code

10 - Combustible liquids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

C Peters et al.
Scientific reports, 6, 31879-31879 (2016-09-02)
Dravet syndrome is the prototype of SCN1A-mutation associated epilepsies. It is characterised by prolonged seizures, typically provoked by fever. We describe the evaluation of an SCN1A mutation in a child with early-onset temperature-sensitive seizures. The patient carries a heterozygous missense
Clara Stead et al.
Journal of biomolecular screening, 21(10), 1042-1053 (2016-07-15)
Glycine receptor 3 (GlyRα3) is a ligand-gated ion channel of the cys-loop family that plays a key role in mediating inhibitory neurotransmission and regulation of pain signaling in the dorsal horn. Potentiation of GlyRα3 function is therefore of interest as
Mena Abdelsayed et al.
The Journal of physiology, 593(18), 4201-4223 (2015-07-02)
Cardiac arrhythmias are often associated with mutations in SCN5A the gene that encodes the cardiac paralogue of the voltage-gated sodium channel, NaV 1.5. The NaV 1.5 mutants R1193Q and E1784K give rise to both long QT and Brugada syndromes. Various
T M Trask et al.
The Journal of biological chemistry, 275(32), 24400-24406 (2000-05-29)
Alignment of tropoelastin molecules during the process of elastogenesis is thought to require fibrillin-containing microfibrils. In this study, we have demonstrated that amino-terminal domains of two microfibrillar proteins, fibrillin-1 and fibrillin-2, interact with tropoelastin in solid phase binding assays. The
Cheng-Yu Chung et al.
Biochemical and biophysical research communications, 463(3), 211-215 (2015-05-23)
In this research, we examined which genes are involved in N-linked sialylation in Chinese Hamster Ovary (CHO) cells using siRNA knockdown approaches. Three genes from the sialyltransferase family (ST3GAL3, ST3GAL4 and ST3GAL6) were chosen as knockdown targets with siRNA applied
View All Related Papers

Articles

Impact of DMSO And Freezing Technique in Developing a High Cell Density Cryopreservation Process for Upstream Bioprocessing

Understand how considerations such as DMSO concentrations and freezing techniques are key in the successful implementation of high cell density cryopreservation (HCDC).

CHO Media and Feeds for Optimized Production of Therapeutic Proteins

Cellvento® and EX-CELL® CHO cell culture media and feeds, optimized for monoclonal antibody & recombinant protein production in fed-batch & perfusion

Related Content

Cell Line Development for mAbs

Learn more about cell line development and the relevant products you need for this process.

Accelerate development and optimization of cell culture media for upstream perfusion processes

This page describes the use of a small-scale perfusion bioreactor with integrated microfluidic flow control and sensor technologies to predict large-scale processes.

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service