- A validated LC-MS/MS method for the determination of tolterodine and its metabolite in rat plasma and application to pharmacokinetic study.
A validated LC-MS/MS method for the determination of tolterodine and its metabolite in rat plasma and application to pharmacokinetic study.
Journal of pharmaceutical analysis (2013-12-01)
Rihana Parveen Shaik, Srinivasa Babu Puttagunta, Chandrasekhar Bannoth Kothapalli, Bahlul Zayed Sh Awen, B R Challa
PMID29403860
ABSTRACT
Liquid chromatography-tandem mass spectrometry (LC-MS/MS) method was used for simultaneous quantification of tolterodine and its metabolite 5-hydroxy methyl tolterodine in rat plasma. Tolterodine-d6 and 5-hydroxy methyl tolterodine-d14 were used as internal standards (IS). Chromatographic separation was performed on Ascentis Express RP amide (50 mm×4.6 mm, 2.7 μm) column with an isocratic mobile phase composed of 10 mM ammonium acetate and acetonitrile in the ratio of 20:80 (v/v), at a flow-rate of 0.5 mL/min. Tolterodine, tolterodine-d6, 5-hydroxy methyl tolterodine and 5-hydroxy methyl tolterodine-d14 were detected with proton adducts at
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Colonna per HPLC Ascentis® Express RP-Amide, 2,7 μm, 2.7 μm particle size, L × I.D. 15 cm × 4.6 mm
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Colonna per HPLC Ascentis® Express RP-Amide, 2,7 μm, 2.7 μm particle size, L × I.D. 10 cm × 2.1 mm
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Colonna per HPLC Ascentis® Express RP-Amide, 2,7 μm, 2.7 μm particle size, L × I.D. 5 cm × 2.1 mm
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Colonna per HPLC Ascentis® Express RP-Amide, 2,7 μm, 2.7 μm particle size, L × I.D. 10 cm × 4.6 mm
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Cartuccia di guardia per Ascentis® Express RP-Amide, 2,7 μm, 2.7 μm particle size, L × I.D. 5 mm × 2.1 mm, pkg of 3 ea
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Colonna per HPLC Ascentis® Express RP-Amide, 2,7 μm, 2.7 μm particle size, L × I.D. 7.5 cm × 4.6 mm
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Colonna per HPLC Ascentis® Express RP-Amide, 2,7 μm, 2.7 μm particle size, L × I.D. 5 cm × 3 mm
Supelco
Colonna per HPLC Ascentis® Express RP-Amide, 2,7 μm, 2.7 μm particle size, L × I.D. 10 cm × 3 mm
Supelco
Colonna per HPLC Ascentis® Express RP-Amide, 2,7 μm, 2.7 μm particle size, L × I.D. 5 cm × 4.6 mm
Supelco
Colonna per HPLC Ascentis® Express RP-Amide, 2,7 μm, 2.7 μm particle size, L × I.D. 7.5 cm × 3 mm
Supelco
Colonna per HPLC Ascentis® Express RP-Amide, 2,7 μm, 2.7 μm particle size, L × I.D. 15 cm × 3 mm
Supelco
Colonna per HPLC Ascentis® Express RP-Amide, 2,7 μm, 2.7 μm particle size, L × I.D. 15 cm × 2.1 mm
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Ascentis® Express RP-Amide, 2 μm UHPLC Column, 2 μm particle size, L × I.D. 5 cm × 2.1 mm
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Ascentis® Express RP-Amide, 2 μm UHPLC Column, 2 μm particle size, L × I.D. 15 cm × 2.1 mm
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Ascentis® RP-Amide Supelguard Guard Cartridge, 5 μm particle size, L × I.D. 2 cm × 4 mm, pkg of 2 ea
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Ascentis® Express RP-Amide, 2 μm UHPLC Column, 2 μm particle size, L × I.D. 10 cm × 2.1 mm
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Ascentis® Express RP-Amide, 5 μm HPLC Column, 5 μm particle size, L × I.D. 10 cm × 4.6 mm
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Ascentis® Express RP-Amide, 5 μm HPLC Column, 5 μm particle size, L × I.D. 15 cm × 4.6 mm
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Ascentis® Express RP-Amide, 5 μm Guard Cartridge, 5 μm particle size, L × I.D. 5 mm × 4.6 mm, pkg of 3 ea
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Ascentis® RP-Amide Supelguard Guard Cartridge, Kit, 5 μm particle size, L × I.D. 2 cm × 4 mm
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Ascentis® Express RP-Amide, 2 μm UHPLC Column, 2 μm particle size, L × I.D. 5 cm × 3 mm