- iRhom2 deficiency relieves TNF-α associated hepatic dyslipidemia in long-term PM2.5-exposed mice.
iRhom2 deficiency relieves TNF-α associated hepatic dyslipidemia in long-term PM2.5-exposed mice.
Biochemical and biophysical research communications (2017-10-03)
Chen-Xu Ge, Yu-Ting Qin, De-Shuai Lou, Qiang Li, Yuan-Yuan Li, Zhong-Ming Wang, Wei-Wei Yang, Ming Wang, Nan Liu, Zhen Wang, Peng-Xing Zhang, Yan-Yang Tu, Jun Tan, Min-Xuan Xu
PMID28965953
ABSTRACT
Accumulating researches reported that particulate matter (PM2.5) is a risk factor for developing various diseases, including metabolic syndrome. Recently, inactive rhomboid protein 2 (iRhom2) was considered as a necessary modulator for shedding of tumor necrosis factor-α (TNF-α) in immune cells. TNF-α, a major pro-inflammatory cytokine, was linked to various pathogenesis of diseases, including dyslipidemia. Here, wild type (WT) and iRhom2-knockout (iRhom2
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