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Merck

Synthesis of

Tetrahedron letters (2015-12-15)
Yousef Beni, Chandravanu Dash, Keykavous Parang
PMID26661734
ABSTRACT

Dinucleoside phosphorochloridite were synthesized from phosphorus trichloride and three nucleoside analogues, 3'-fluoro-2',3'-dideoxythymidine (FLT), 2',3'-dideoxy-5-fluoro-3'-thiacytidine (FTC), and 2',3'-dideoxy-3'-thiacytidine (3TC), in a multistep synthesis. Polymer-bound