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  • Role of the recently identified dysadherin in E-cadherin adhesion molecule downregulation in head and neck cancer.

Role of the recently identified dysadherin in E-cadherin adhesion molecule downregulation in head and neck cancer.

Medical oncology (Northwood, London, England) (2011-11-23)
Alexandros Georgolios, Anna Eleftheriadou, Anna Batistatou, Kostandinos Charalabopoulos
ABSTRACT

Dysadherin is a cancer-related cell membrane glycoprotein, recently identified, playing an important role in tumor progression and metastasis. In the present minireview article, we are focusing on the role of dysadherin in E-cadherin downregulation, the various expression patterns of the molecule in head and neck cancer as well as its potential role as a molecular target for future applications in diagnosis, clinical routine and prognosis of the disease.