Passa al contenuto
Merck

Palladium-catalyzed insertion of α-diazocarbonyl compounds for the synthesis of cyclic amino esters.

Chemical communications (Cambridge, England) (2012-12-05)
Ping-Xin Zhou, Zhao-Zhao Zhou, Zi-Sheng Chen, Yu-Ying Ye, Lian-Biao Zhao, Yan-Fang Yang, Xiao-Feng Xia, Jian-Yi Luo, Yong-Min Liang
ABSTRACT

Two different cyclic amino esters are synthesized by palladium-catalyzed cross-coupling reaction of diazoesters with N-substituted-2-iodoanilines. Aryldiazoacetates lead to cyclic α-amino esters with an α-quaternary carbon centre in the presence of CO. Additionally, arylvinyldiazoacetates afford cyclic α,β-unsaturated γ-amino esters.

MATERIALI
N° Catalogo
Marchio
Descrizione del prodotto

Sigma-Aldrich
Aniline, ACS reagent, ≥99.5%
Sigma-Aldrich
Aniline hydrochloride, ≥99%
Sigma-Aldrich
Aniline, ReagentPlus®, 99%
Supelco
Aniline, analytical standard
Sigma-Aldrich
Aniline-15N, 98 atom % 15N
Supelco
Aniline solution, certified reference material, 5000 μg/mL in methanol
Sigma-Aldrich
Aniline-1-13C, 99 atom % 13C
Sigma-Aldrich
Aniline-4-13C, 99 atom % 13C