- Palladium-catalyzed insertion of α-diazocarbonyl compounds for the synthesis of cyclic amino esters.
Palladium-catalyzed insertion of α-diazocarbonyl compounds for the synthesis of cyclic amino esters.
Chemical communications (Cambridge, England) (2012-12-05)
Ping-Xin Zhou, Zhao-Zhao Zhou, Zi-Sheng Chen, Yu-Ying Ye, Lian-Biao Zhao, Yan-Fang Yang, Xiao-Feng Xia, Jian-Yi Luo, Yong-Min Liang
PMID23208611
ABSTRACT
Two different cyclic amino esters are synthesized by palladium-catalyzed cross-coupling reaction of diazoesters with N-substituted-2-iodoanilines. Aryldiazoacetates lead to cyclic α-amino esters with an α-quaternary carbon centre in the presence of CO. Additionally, arylvinyldiazoacetates afford cyclic α,β-unsaturated γ-amino esters.
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