Lipase catalysed synthesis of optically enriched alpha-haloamides.

Lipase catalysed synthesis of optically enriched alpha-haloamides.

Bioorganic & medicinal chemistry (2001-05-30)

A Azim, S K Sharma, C E Olsen, V S Parmar

ABSTRACT

An efficient lipase catalysed synthesis of optically enriched alpha-halogenated amides with concomitant optical enrichment of the starting alpha-haloesters is described. Candida antarctica lipase (CAL) was found to be a better catalyst over porcine pancreatic lipase (PPL) and Candida cylindracea lipase (CCL). The effect of different organic solvents was also studied.

MATERIALI

N° Catalogo

Marchio

Descrizione del prodotto

38270

Sigma-Aldrich

Diisopropyl ether, puriss. p.a., ≥98.5% (GC)

185302

Sigma-Aldrich

Diisopropyl ether, ReagentPlus^®, 99%, contains either BHT or hydroquinone as stabilizer

398276

Sigma-Aldrich

Diisopropyl ether, contains either BHT or hydroquinone as stabilizer, ACS reagent, ≥99.0%

296856

Sigma-Aldrich

Diisopropyl ether, anhydrous, 99%, contains either BHT or hydroquinone as stabilizer

673803

Sigma-Aldrich

Diisopropyl ether, contains either BHT or hydroquinone as stabilizer, ACS reagent, ≥99.0%

95251

Supelco

Diisopropyl ether, analytical standard