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  • Amino acids and peptides. XVI. Synthesis of N-terminal tetrapeptide analogs of fibrin alpha-chain and their inhibitory effects on fibrinogen/thrombin clotting.

Amino acids and peptides. XVI. Synthesis of N-terminal tetrapeptide analogs of fibrin alpha-chain and their inhibitory effects on fibrinogen/thrombin clotting.

Chemical & pharmaceutical bulletin (1992-12-01)
K Kawasaki, K Hirase, M Miyano, T Tsuji, M Iwamoto
ABSTRACT

N-Terminal tetrapeptide analogs of fibrin alpha-chain were synthesized by the solution method using a new active ester, the ester of the oxime of p-nitroacetophenone, and by the solid-phase method. Their inhibitory effects on fibrinogen/thrombin clotting were examined. Of the synthetic peptides, amide analogs of Gly-Pro-Arg-Pro exhibited a more potent inhibitory effect.

MATERIALI
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Descrizione del prodotto

Sigma-Aldrich
Gly-Pro-Arg-Pro amide, ≥97% (HPLC)