- Vitamin D receptor agonist/histone deacetylase inhibitor molecular hybrids.
Vitamin D receptor agonist/histone deacetylase inhibitor molecular hybrids.
Bioorganic & medicinal chemistry (2010-05-11)
Marc Lamblin, Basel Dabbas, Russell Spingarn, Rodrigo Mendoza-Sanchez, Tian-Tian Wang, Beum-Soo An, Dao Chao Huang, Richard Kremer, John H White, James L Gleason
PMID20452225
ABSTRACT
Incorporation of zinc-binding groups into the side-chain of 1alpha,25-dihydroxyvitamin D(3) (1,25D) fully bifunctional hybrid molecules which act both as vitamin D receptor agonists and histone deacetylase inhibitors. These bifunctional hybrids display in vitro antiproliferative activity against the AT84 squamous carcinoma cell line while lacking the in vivo hypercalcemic effects of 1,25D.
MATERIALI
N° Catalogo
Marchio
Descrizione del prodotto