- Semi-synthetic analogs of pinitol as potential inhibitors of TNF-alpha cytokine expression in human neutrophils.
Semi-synthetic analogs of pinitol as potential inhibitors of TNF-alpha cytokine expression in human neutrophils.
Bioorganic & medicinal chemistry letters (2009-03-10)
Khurshid A Bhat, Bhahwal A Shah, Kuldeep K Gupta, Anjali Pandey, Sarang Bani, Subhash C Taneja
PMID19268586
ABSTRACT
Semi-synthetic analogs of pinitol were subjected to screening by determining TNF-alpha expression in human neutrophils using flowcytometry. Among the tested compounds, three derivatives displayed more than 50% inhibition of TNF-alpha cytokine secretion in LPS induced stimulated neutrophils and can be considered as potent anti-inflammatory moieties.
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