SRP5222
MSK2, active, GST tagged from mouse
PRECISIO® Kinase, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution
Sinonimo/i:
RPS6KA4, RSK-B, RSKB
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About This Item
Codice UNSPSC:
12352200
NACRES:
NA.32
Ricombinante
expressed in baculovirus infected Sf9 cells
Nome Commerciale
PRECISIO® Kinase
Saggio
≥70% (SDS-PAGE)
Forma fisica
buffered aqueous glycerol solution
Attività specifica
7.5-10.4 nmol/min·mg
PM
~114 kDa
N° accesso NCBI
Condizioni di spedizione
dry ice
Temperatura di conservazione
−70°C
Informazioni sul gene
mouse ... Rps6ka4(56613)
Descrizione generale
MSK2 (mitogen- and stress-activated protein kinase-2) is a member of the serine/threonine kinase family that contains two non-identical kinase catalytic domains. MSK2 is also known as ribosomal protein S6 kinase polypeptide 4 (RPS6KA4), that is activated by the mitogen-activated protein kinases- extracellular signal-regulated kinases 1 and 2 (ERK1 and -2) and p38.
Azioni biochim/fisiol
MSK2 (mitogen- and stress-activated protein kinase-2) phosphorylates various substrates like cyclic AMP-responsive element-binding protein 1 (CREB1) and the proto-oncogene c-fos. It is a histone-modifying enzyme and a mitogenic factor. The protein is involved in the G1-phase of the cell cycle and has a role in apoptosis. It also modulates the functions of various transcription factors.
Stato fisico
Supplied in 50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol.
Nota sulla preparazione
after opening, aliquot into smaller quantities and store at -70 °C. Avoid repeating handling and multiple freeze/thaw cycles
Note legali
PRECISIO is a registered trademark of Merck KGaA, Darmstadt, Germany
Codice della classe di stoccaggio
10 - Combustible liquids
Classe di pericolosità dell'acqua (WGK)
WGK 1
Certificati d'analisi (COA)
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I documenti relativi ai prodotti acquistati recentemente sono disponibili nell’Archivio dei documenti.
Accelerated apoptotic death and in vivo turnover of erythrocytes in mice lacking functional mitogen- and stress-activated kinase MSK1/2.
Lang E
Scientific Reports, 5, 17316-17316 (2015)
ERK and p38 MAPK-activated protein kinases: a family of protein kinases with diverse biological functions.
Roux PP and Blenis J
Microbiology and Molecular Biology Reviews, 68(2), 320-344 (2004)
Mitogen and stress-activated kinases 1/2 regulate ischemia-induced hippocampal progenitor cell proliferation and neurogenesis.
Karelina K
Neuroscience, 285, 292-302 (2015)
Comparison of epigenetic mediator expression and function in mouse and human embryonic blastomeres.
Chavez SL, McElroy SL, Bossert NL, et al.
Human Molecular Genetics, 23(18), 4970-4984 (2014)
B Pierrat et al.
The Journal of biological chemistry, 273(45), 29661-29671 (1998-10-29)
A novel ribosomal S6 kinase (RSK) family member, RSK-B, was identified in a p38alphaMAPK-baited intracellular interaction screen. RSK-B presents two catalytic domains typical for the RSK family. The protein kinase C-like N-terminal and the calcium/calmodulin kinase-like C-terminal domains both contain
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