SRP0351

PDGFRb active human

recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE)

• Sinonimo/i: CD140B, JTK12, platelet-derived growth factor receptor, beta polypeptide
• Numero CAS: 101463-26-7
• Codice UNSPSC: 12352200
• NACRES: NA.32

Proprietà

• Origine biologica: human
• Ricombinante: expressed in baculovirus infected Sf9 cells
• Saggio: ≥70% (SDS-PAGE)
• Stato: aqueous solution
• PM: 62 kDa
• Confezionamento: pkg of 10 μg
• tecniche: activity assay: suitable; inhibition assay: suitable
• Solubilità: soluble; water: soluble
• N° accesso NCBI: NM_002609
• N° accesso UniProt: P09619
• Condizioni di spedizione: dry ice
• Temperatura di conservazione: −70°C
• Informazioni sul gene: human ... PDGFRB(5159)

Descrizione

Descrizione generale

Research area: Cell Cycle

Human PDGFRbeta (GenBank Accession No. NM_002609), cytoplasmic domain, amino acids 558-1106 (end) with N-terminal His-tag, MW= 62 kDa, expressed in Sf9 cells via a Baculovirus expression system.

Platelet-derived growth factor receptor (PDGFR) belongs to subclass III of receptor tyrosine kinases.[1] The PDGFR exists as two isoforms, PDGFa and PDGFb-receptors, consisting of five extracellular immunoglobulin (Ig) loops and an intracellular tyrosine kinase (TK) domain. [2]

Applicazioni

Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling.

Azioni biochim/fisiol

The PDGFβ receptor is involved in the development of the kidney, heart, placenta, [3] blood vessels, and cardiovascular system. It also helps to regulate interstitial fluid pressure in tissues thus preventing edema. The activation of the PDGFβ receptor plays a crucial role in the process of wound healing. [3] In addition to these functions, its overexpression is related to gastric cancer.[4]

Informazioni sulla sicurezza

• Pittogrammi: GHS08,GHS07
• Avvertenze: Danger
• Indicazioni di pericolo: H315,H319,H360D
• Consigli di prudenza: P202 - P264 - P280 - P302 + P352 - P305 + P351 + P338 - P308 + P313
• Classi di pericolo: Eye Irrit. 2 - Repr. 1B - Skin Irrit. 2
• Codice della classe di stoccaggio: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• Classe di pericolosità dell'acqua (WGK): WGK 1
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable