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SAB4200530

Sigma-Aldrich

Anti-ZNF746 antibody produced in rabbit

enhanced validation

~1.0 mg/mL, affinity isolated antibody

Sinonimo/i:

Anti-Parkin-interacting Substrate, PARIS

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About This Item

Codice UNSPSC:
12352203
NACRES:
NA.41

Origine biologica

rabbit

Coniugato

unconjugated

Forma dell’anticorpo

affinity isolated antibody

Tipo di anticorpo

primary antibodies

Clone

polyclonal

Forma fisica

buffered aqueous solution

PM

antigen ~90 kDa

Reattività contro le specie

rat, mouse, human

Convalida avanzata

recombinant expression
Learn more about Antibody Enhanced Validation

Concentrazione

~1.0 mg/mL

tecniche

indirect immunofluorescence: 2.5-5.0 μg/mL using SH-SY-5Y cells.
western blot: 1.0-2.0 μg/mL using using rat brain extracts (S2 fraction) and NIH3T3 fibroblast cell extracts.

N° accesso UniProt

Q6NUN9

Condizioni di spedizione

dry ice

Temperatura di conservazione

−20°C

modifica post-traduzionali bersaglio

unmodified

Informazioni sul gene

human ... ZNF746(155061)
mouse ... Zfp746(69228)
rat ... Zfp746(312303)

Descrizione generale

Zinc finger protein 746, also known as PARIS, parkin interacting substrate (ZNF746 ) is a 644 amino acid protein. It has a Kruppel-associated box (KRAB) at its N-terminal and a C2HC/C2H2 type zinc finger at its C terminals. This protein is highly conserved among human, mouse and rat, and widely expressed in many tissues.

Immunogeno

synthetic peptide corresponding to an internal sequence of human ZNF746, conjugated to KLH. The corresponding sequence is identical in human ZNF746 isoform 2, and in mouse and rat ZNF746.

Applicazioni

Anti-ZNF746 antibody produced in rabbit has been used in immunoblotting and immunofluorescence.

Azioni biochim/fisiol

Zinc finger protein 746, also known as PARIS, parkin interacting substrate (ZNF746 ) accumulates in Parkinson′s disease (PD) models and in human PD brain. Hence it play a role in the progress of PD disease. ZNF746 is also regulated by the E3 ubiquitin ligase, parkin. In addition, overexpression of ZNF746 leads to the selective loss of dopaminergic neurons in the substantia nigra.

Stato fisico

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

Esclusione di responsabilità

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Codice della classe di stoccaggio

10 - Combustible liquids

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Certificati d'analisi (COA)

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Zinc finger protein 746 promotes colorectal cancer progression via c-Myc stability mediated by glycogen synthase kinase 3 beta and F-box and WD repeat domain-containing 7
Jung JH, et al.
Oncogene, 1-1 (2018)
Joo-Ho Shin et al.
Cell, 144(5), 689-702 (2011-03-08)
A hallmark of Parkinson's disease (PD) is the preferential loss of substantia nigra dopamine neurons. Here, we identify a new parkin interacting substrate, PARIS (ZNF746), whose levels are regulated by the ubiquitin proteasome system via binding to and ubiquitination by

Il team dei nostri ricercatori vanta grande esperienza in tutte le aree della ricerca quali Life Science, scienza dei materiali, sintesi chimica, cromatografia, discipline analitiche, ecc..

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