P4533
Calpain II from rabbit skeletal muscle
lyophilized powder, 15-40 units/mg protein
Sinonimo/i:
Calcium Activated Neutral Protease
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About This Item
Numero CAS:
Numero MDL:
Codice UNSPSC:
12352202
Prodotti consigliati
Origine biologica
rabbit skeletal muscle
Livello qualitativo
Stato
lyophilized powder
Attività specifica
15-40 units/mg protein
Composizione
Protein, 2-10% Lowry
Concentrazione
2-10% protein (Lowry)
N° accesso UniProt
Temperatura di conservazione
−20°C
Informazioni sul gene
rabbit ... CAPN2(100009092)
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Azioni biochim/fisiol
Calpain undergoes translocation between cell compartments during the various steps of the cell cycle. It is among the proteases implicated in apoptosis and the proteasome-ubiquitine pathway of protein degradation.
Altre note
80K subunit of mCANP
Definizione di unità
One unit will produce a ΔA280 of 0.5 in 30 min at pH 7.5 at 30 °C, measured as TCA soluble products using N,N-dimethylated casein as substrate. (Final volume = 1.8 mL, light path = 1 cm.) (Modified from Kawashima, S., et al.)
Stato fisico
Lyophilized powder containing lactose, dithiothreitol and tris buffer salts.
Inibitore
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Substrato
N° Catalogo
Descrizione
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Codice della classe di stoccaggio
11 - Combustible Solids
Classe di pericolosità dell'acqua (WGK)
WGK 3
Punto d’infiammabilità (°F)
Not applicable
Punto d’infiammabilità (°C)
Not applicable
Dispositivi di protezione individuale
Eyeshields, Gloves, type N95 (US)
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E Solary et al.
Cell biology and toxicology, 14(2), 121-132 (1998-04-29)
Proteolytic cleavage of a limited number of cellular proteins is a central biochemical feature of apoptosis. Aspartate-specific cysteine proteases, the so-called 'caspases', are the main enzymes involved in this process. At least ten homologues of interleukin-1 beta converting enzyme (ICE)
S Kawashima et al.
Journal of biochemistry, 95(1), 95-101 (1984-01-01)
Calcium-activated neutral proteases (CANPs) were purified from rabbit skeletal muscle and chicken skeletal muscle, and compared as to their electrophoretic properties, metal requirements, subunit amino acid compositions and immunological cross-reactivities. Two kinds of CANPs (mu CANP and mCANP) were isolated
L Santella et al.
Cell calcium, 23(2-3), 123-130 (1998-05-28)
Proteolysis is a key event in the control of the cell cycle. Most of the proteins which are degraded at specific cycle points, e.g. cyclins A, B, and E, are substrates of the ubiquitin/proteasome pathway. The Ca2+ dependent neutral protease
S Tsuji et al.
Journal of biochemistry, 90(1), 233-240 (1981-07-01)
The structure of the calcium-activated neutral proteinase (CANP) from rabbit skeletal muscle was examined. The purified CANP was homogeneous as judged by disc gel electrophoresis, while it showed two bands (M.W.=80,000 (80 K) and 31,000 (30 K) on SDS-gel electrophoresis.
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